Gene description for ADAM19
Gene name ADAM metallopeptidase domain 19
Gene symbol ADAM19
Other names/aliases FKSG34
MADDAM
MLTNB
Species Homo sapiens
 Database cross references - ADAM19
ExoCarta ExoCarta_8728
Vesiclepedia VP_8728
Entrez Gene 8728
HGNC 197
MIM 603640
UniProt Q9H013  
 ADAM19 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ADAM19
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 IMP
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 IEA
    metal ion binding GO:0046872 IEA
    metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO:1902945 IMP
Biological Process
    placenta development GO:0001890 IEP
    membrane protein ectodomain proteolysis GO:0006509 IBA
    positive regulation of gene expression GO:0010628 IDA
    protein processing GO:0016485 IMP
    amyloid precursor protein catabolic process GO:0042987 IMP
    positive regulation of cell-cell adhesion mediated by cadherin GO:2000049 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 TAS
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified ADAM19 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADAM19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 KPTN  
Affinity Capture-MS Homo sapiens
3 ELSPBP1  
Affinity Capture-MS Homo sapiens
4 BTNL2  
Affinity Capture-MS Homo sapiens
5 TMEM106A  
Affinity Capture-MS Homo sapiens
6 KLK15  
Affinity Capture-MS Homo sapiens
7 THUMPD3 25917
Affinity Capture-MS Homo sapiens
8 ITFG2  
Affinity Capture-MS Homo sapiens
9 ACTA2 59
Affinity Capture-MS Homo sapiens
10 TMEM255B  
Affinity Capture-MS Homo sapiens
11 CFC1  
Affinity Capture-MS Homo sapiens
12 MFAP4 4239
Affinity Capture-MS Homo sapiens
13 ECEL1  
Affinity Capture-MS Homo sapiens
14 HSPA14 51182
Affinity Capture-MS Homo sapiens
15 NCR3  
Affinity Capture-MS Homo sapiens
16 SFTPC  
Affinity Capture-MS Homo sapiens
17 COPB1 1315
Two-hybrid Homo sapiens
18 ACTA1 58
Affinity Capture-MS Homo sapiens
19 NRBP1 29959
Affinity Capture-MS Homo sapiens
20 ABI2 10152
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
21 TSC22D1 8848
Affinity Capture-MS Homo sapiens
22 SDF2L1 23753
Affinity Capture-MS Homo sapiens
23 FIBIN  
Affinity Capture-MS Homo sapiens
24 DNAJB9 4189
Affinity Capture-MS Homo sapiens
25 TSC22D2 9819
Affinity Capture-MS Homo sapiens
26 TUBB7P 56604
Affinity Capture-MS Homo sapiens
27 TSC22D3  
Affinity Capture-MS Homo sapiens
28 SH3GL2  
Two-hybrid Homo sapiens
29 GKN2  
Affinity Capture-MS Homo sapiens
30 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
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