Gene description for ALKBH7
Gene name alkB, alkylation repair homolog 7 (E. coli)
Gene symbol ALKBH7
Other names/aliases ABH7
SPATA11
UNQ6002
Species Homo sapiens
 Database cross references - ALKBH7
ExoCarta ExoCarta_84266
Entrez Gene 84266
HGNC 21306
MIM 613305
UniProt Q9BT30  
 ALKBH7 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ALKBH7
Molecular Function
    metal ion binding GO:0046872 IEA
    dioxygenase activity GO:0051213 IEA
Biological Process
    cellular response to DNA damage stimulus GO:0006974 IDA
    regulation of lipid storage GO:0010883 ISS
    regulation of mitochondrial membrane permeability involved in programmed necrotic cell death GO:1902445 IMP
    fatty acid metabolic process GO:0006631 ISS
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    mitochondrial matrix GO:0005759 IDA
 Experiment description of studies that identified ALKBH7 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ALKBH7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ALKBH7 is involved
No pathways found





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