Gene description for Grhpr
Gene name glyoxylate reductase/hydroxypyruvate reductase
Gene symbol Grhpr
Other names/aliases 1110059D05Rik
6430629L09Rik
Species Mus musculus
 Database cross references - Grhpr
ExoCarta ExoCarta_76238
Vesiclepedia VP_76238
Entrez Gene 76238
UniProt Q91Z53  
 Grhpr identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Grhpr
Molecular Function
    hydroxypyruvate reductase (NADH) activity GO:0008465 IBA
    hydroxypyruvate reductase (NADH) activity GO:0008465 IEA
    hydroxypyruvate reductase (NADH) activity GO:0008465 ISO
    hydroxypyruvate reductase [NAD(P)H] activity GO:0016618 ISO
    glyoxylate reductase (NADPH) activity GO:0030267 IBA
    glyoxylate reductase (NADPH) activity GO:0030267 IEA
    glyoxylate reductase (NADPH) activity GO:0030267 ISO
    carboxylic acid binding GO:0031406 IEA
    carboxylic acid binding GO:0031406 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    NADP binding GO:0050661 ISO
    NAD binding GO:0051287 IEA
    NAD binding GO:0051287 ISO
    NADPH binding GO:0070402 IEA
    NADPH binding GO:0070402 ISO
    hydroxypyruvate reductase (NADPH) activity GO:0120509 IEA
Biological Process
    dicarboxylic acid metabolic process GO:0043648 IEA
    dicarboxylic acid metabolic process GO:0043648 ISO
    glyoxylate metabolic process GO:0046487 IEA
    glyoxylate metabolic process GO:0046487 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    catalytic complex GO:1902494 IEA
    catalytic complex GO:1902494 ISO
 Experiment description of studies that identified Grhpr in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Grhpr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Grhpr 76238
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here