Gene description for TGFB3
Gene name transforming growth factor, beta 3
Gene symbol TGFB3
Other names/aliases ARVD
ARVD1
RNHF
TGF-beta3
Species Homo sapiens
 Database cross references - TGFB3
ExoCarta ExoCarta_7043
Vesiclepedia VP_7043
Entrez Gene 7043
HGNC 11769
MIM 190230
UniProt P10600  
 TGFB3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TGFB3
Molecular Function
    type II transforming growth factor beta receptor binding GO:0005114 IDA
    type II transforming growth factor beta receptor binding GO:0005114 IMP
    type II transforming growth factor beta receptor binding GO:0005114 IPI
    cytokine activity GO:0005125 IBA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    type I transforming growth factor beta receptor binding GO:0034713 IDA
    type III transforming growth factor beta receptor binding GO:0034714 IMP
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 IPI
    protein-containing complex binding GO:0044877 IEA
    transforming growth factor beta binding GO:0050431 IDA
Biological Process
    response to hypoxia GO:0001666 IDA
    in utero embryonic development GO:0001701 ISS
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 ISS
    salivary gland morphogenesis GO:0007435 IEP
    female pregnancy GO:0007565 IEA
    positive regulation of cell population proliferation GO:0008284 IMP
    negative regulation of cell population proliferation GO:0008285 IMP
    positive regulation of epithelial to mesenchymal transition GO:0010718 IDA
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISS
    negative regulation of macrophage cytokine production GO:0010936 IDA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA
    mammary gland development GO:0030879 ISS
    response to progesterone GO:0032570 IDA
    positive regulation of collagen biosynthetic process GO:0032967 IMP
    response to laminar fluid shear stress GO:0034616 IEA
    regulation of cell population proliferation GO:0042127 IBA
    odontogenesis GO:0042476 NAS
    uterine wall breakdown GO:0042704 TAS
    positive regulation of apoptotic process GO:0043065 ISS
    positive regulation of MAPK cascade GO:0043410 IEA
    negative regulation of neuron apoptotic process GO:0043524 ISS
    response to estrogen GO:0043627 IEA
    cell-cell junction organization GO:0045216 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    lung alveolus development GO:0048286 ISS
    digestive tract development GO:0048565 IEA
    embryonic neurocranium morphogenesis GO:0048702 IEA
    inner ear development GO:0048839 IEA
    positive regulation of protein secretion GO:0050714 IDA
    positive regulation of filopodium assembly GO:0051491 ISS
    positive regulation of stress fiber assembly GO:0051496 IDA
    positive regulation of cell division GO:0051781 IEA
    face morphogenesis GO:0060325 IMP
    frontal suture morphogenesis GO:0060364 IEA
    positive regulation of SMAD protein signal transduction GO:0060391 ISS
    secondary palate development GO:0062009 ISS
    detection of hypoxia GO:0070483 IDA
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IDA
    regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905005 ISS
    positive regulation of tight junction disassembly GO:1905075 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 IC
    cell surface GO:0009986 IEA
    T-tubule GO:0030315 IEA
    platelet alpha granule lumen GO:0031093 TAS
    neuronal cell body GO:0043025 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    collagen-containing extracellular matrix GO:0062023 IDA
 Experiment description of studies that identified TGFB3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TGFB3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP2A 27243
Two-hybrid Homo sapiens
2 CCL20 6364
Two-hybrid Homo sapiens
3 VASN 114990
Reconstituted Complex Homo sapiens
4 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
5 TGFBR2 7048
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
6 SDC4 6385
Two-hybrid Homo sapiens
View the network image/svg+xml



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