Gene description for Lap3
Gene name
leucine aminopeptidase 3
Gene symbol
Lap3
Other names/aliases
2410015L10Rik AA410100 LAP-3 Lap Lapep Pep-7 Pep-S Pep7 Peps
Species
Mus musculus
Database cross references - Lap3
ExoCarta
ExoCarta_66988
Vesiclepedia
VP_66988
Entrez Gene
66988
UniProt
Q9CPY7
Lap3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells
37309723
T-cell lymphoma cells
37309723
Gene ontology annotations for Lap3
Experiment description of studies that identified Lap3 in sEVs
1
Experiment ID
907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
37309723
Organism
Mus musculus
Experiment description
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors
"Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name
Proteomics
Publication year
2023
Sample
Colon cancer cells
Sample name
C26
Isolation/purification methods
Differential centrifugation Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
2
Experiment ID
908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
37309723
Organism
Mus musculus
Experiment description
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors
"Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name
Proteomics
Publication year
2023
Sample
T-cell lymphoma cells
Sample name
EL4
Isolation/purification methods
Differential centrifugation Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
Protein-protein interactions for Lap3
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
Tfe3
Affinity Capture-MS
Mus musculus
2
Tia1
Affinity Capture-MS
Mus musculus
3
Mettl21e
Affinity Capture-MS
Mus musculus
4
Lap3
66988
Cross-Linking-MS (XL-MS)
Mus musculus
Cross-Linking-MS (XL-MS)
Mus musculus
5
Trappc2l
Co-fractionation
Mus musculus
View the network
image/svg+xml
Pathways in which Lap3 is involved
No pathways found