Gene description for Lap3
Gene name leucine aminopeptidase 3
Gene symbol Lap3
Other names/aliases 2410015L10Rik
AA410100
LAP-3
Lap
Lapep
Pep-7
Pep-S
Pep7
Peps
Species Mus musculus
 Database cross references - Lap3
ExoCarta ExoCarta_66988
Vesiclepedia VP_66988
Entrez Gene 66988
UniProt Q9CPY7  
 Lap3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lap3
Molecular Function
    carboxypeptidase activity GO:0004180 IEA
    peptidase activity GO:0008233 IBA
    peptidase activity GO:0008233 IDA
    manganese ion binding GO:0030145 IEA
    metalloaminopeptidase activity GO:0070006 IEA
Biological Process
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HDA
    trans-Golgi network GO:0005802 ISO
 Experiment description of studies that identified Lap3 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lap3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tfe3  
Affinity Capture-MS Mus musculus
2 Tia1  
Affinity Capture-MS Mus musculus
3 Mettl21e  
Affinity Capture-MS Mus musculus
4 Lap3 66988
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
5 Trappc2l  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Lap3 is involved
No pathways found





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