Gene description for Twsg1
Gene name twisted gastrulation homolog 1 (Drosophila)
Gene symbol Twsg1
Other names/aliases 1810013J15Rik
9030422N06Rik
AW552143
D17Ertd403e
Tsg
Twg
Species Mus musculus
 Database cross references - Twsg1
ExoCarta ExoCarta_65960
Vesiclepedia VP_65960
Entrez Gene 65960
UniProt Q9EP52  
 Twsg1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Twsg1
Molecular Function
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IDA
    transforming growth factor beta binding GO:0050431 IEA
    transforming growth factor beta binding GO:0050431 ISO
Biological Process
    ossification GO:0001503 IMP
    mesoderm formation GO:0001707 IGI
    negative regulation of cytokine production GO:0001818 IEA
    negative regulation of cytokine production GO:0001818 ISO
    chondrocyte differentiation GO:0002062 IMP
    salivary gland morphogenesis GO:0007435 IMP
    embryo development GO:0009790 IMP
    tissue development GO:0009888 IGI
    hemopoiesis GO:0030097 IMP
    BMP signaling pathway GO:0030509 IGI
    regulation of BMP signaling pathway GO:0030510 IBA
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IEA
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 ISO
    positive regulation of BMP signaling pathway GO:0030513 IMP
    negative regulation of BMP signaling pathway GO:0030514 IDA
    negative regulation of BMP signaling pathway GO:0030514 IMP
    forebrain development GO:0030900 IGI
    forebrain development GO:0030900 IMP
    camera-type eye development GO:0043010 IGI
    negative regulation of osteoblast differentiation GO:0045668 IDA
    positive regulation of SMAD protein signal transduction GO:0060391 IEA
    positive regulation of SMAD protein signal transduction GO:0060391 ISO
    negative regulation of CD4-positive, alpha-beta T cell activation GO:2000515 ISO
    negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562 IEA
    negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified Twsg1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Twsg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Bmp1 12153
Co-fractionation Mus musculus
2 Bmp7  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Twsg1 is involved
No pathways found





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