Gene description for Bmp1
Gene name bone morphogenetic protein 1
Gene symbol Bmp1
Other names/aliases Pcp
Tld
Species Mus musculus
 Database cross references - Bmp1
ExoCarta ExoCarta_12153
Vesiclepedia VP_12153
Entrez Gene 12153
UniProt P98063  
 Bmp1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Bmp1
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 IDA
    metalloendopeptidase activity GO:0004222 TAS
    cytokine activity GO:0005125 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    peptidase activity GO:0008233 ISO
    zinc ion binding GO:0008270 IEA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    ossification GO:0001503 IEA
    proteolysis GO:0006508 IEA
    proteolysis GO:0006508 ISO
    signal transduction GO:0007165 IEA
    dorsal/ventral pattern formation GO:0009953 IBA
    protein processing GO:0016485 IBA
    cell differentiation GO:0030154 IEA
    cartilage development GO:0051216 IEA
    positive regulation of cartilage development GO:0061036 ISO
Subcellular Localization
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    Golgi apparatus GO:0005794 IEA
    vesicle GO:0031982 IEA
    vesicle GO:0031982 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified Bmp1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Bmp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lama3  
Co-fractionation Mus musculus
2 Twsg1 65960
Co-fractionation Mus musculus
3 Lamb3  
Co-fractionation Mus musculus
4 Sfrp2  
Reconstituted Complex Mus musculus
5 Col1a1 12842
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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