Gene description for Sirt2
Gene name	sirtuin 2
Gene symbol	Sirt2
Other names/aliases	5730427M03Rik SIR2L2 Sir2l
Species	Mus musculus
Database cross references - Sirt2
ExoCarta	ExoCarta_64383
Vesiclepedia	VP_64383
Entrez Gene	64383
UniProt	Q8VDQ8
Sirt2 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes	21136642

Gene ontology annotations for Sirt2

Molecular Function     chromatin binding GO:0003682 ISO     chromatin binding GO:0003682 ISS     NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IEA     histone deacetylase activity GO:0004407 IMP     histone deacetylase activity GO:0004407 ISO     histone deacetylase activity GO:0004407 ISS     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     zinc ion binding GO:0008270 ISO     histone deacetylase activity, NAD-dependent GO:0017136 IBA     histone deacetylase activity, NAD-dependent GO:0017136 ISO     histone deacetylase activity, NAD-dependent GO:0017136 ISS     histone H3K14 deacetylase activity, NAD-dependent GO:0032041 IEA     protein lysine deacetylase activity GO:0033558 IDA     protein lysine deacetylase activity GO:0033558 IMP     protein lysine deacetylase activity GO:0033558 ISO     NAD-dependent protein lysine deacetylase activity GO:0034979 IDA     NAD-dependent protein lysine deacetylase activity GO:0034979 ISO     NAD-dependent protein lysine deacetylase activity GO:0034979 ISS     histone acetyltransferase binding GO:0035035 ISO     histone acetyltransferase binding GO:0035035 ISS     histone deacetylase binding GO:0042826 ISO     histone deacetylase binding GO:0042826 ISS     tubulin deacetylase activity GO:0042903 IMP     tubulin deacetylase activity GO:0042903 ISO     tubulin deacetylase activity GO:0042903 ISS     ubiquitin binding GO:0043130 ISO     ubiquitin binding GO:0043130 ISS     histone H3K9 deacetylase activity, NAD-dependent GO:0046969 IEA     histone H4K16 deacetylase activity, NAD-dependent GO:0046970 ISO     histone H4K16 deacetylase activity, NAD-dependent GO:0046970 ISS     NAD+ binding GO:0070403 IBA     NAD+ binding GO:0070403 IEA     NAD+ binding GO:0070403 ISO     histone H3K18 deacetylase activity, NAD-dependent GO:0097372 IEA     DNA-binding transcription factor binding GO:0140297 ISO     DNA-binding transcription factor binding GO:0140297 ISS     histone H3K56 deacetylase activity, NAD-dependent GO:0140765 IEA     NAD-dependent protein demyristoylase activity GO:0140773 ISO     NAD-dependent protein demyristoylase activity GO:0140773 ISS     NAD-dependent protein depalmitoylase activity GO:0140774 ISO     NAD-dependent protein depalmitoylase activity GO:0140774 ISS     histone H3K4 deacetylase activity, NAD-dependent GO:0141222 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     rDNA heterochromatin formation GO:0000183 IBA     chromatin organization GO:0006325 IGI     protein deacetylation GO:0006476 IDA     protein deacetylation GO:0006476 IMP     protein deacetylation GO:0006476 ISO     autophagy GO:0006914 IEA     negative regulation of autophagy GO:0010507 ISO     negative regulation of autophagy GO:0010507 ISS     negative regulation of peptidyl-threonine phosphorylation GO:0010801 IMP     lipid catabolic process GO:0016042 IMP     myelination in peripheral nervous system GO:0022011 IMP     myelination in peripheral nervous system GO:0022011 ISO     regulation of myelination GO:0031641 IMP     regulation of myelination GO:0031641 ISO     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS     cellular response to oxidative stress GO:0034599 IDA     peptidyl-lysine deacetylation GO:0034983 ISO     peptidyl-lysine deacetylation GO:0034983 ISS     epigenetic regulation of gene expression GO:0040029 IMP     epigenetic regulation of gene expression GO:0040029 ISO     negative regulation of protein catabolic process GO:0042177 ISO     negative regulation of protein catabolic process GO:0042177 ISS     negative regulation of apoptotic process GO:0043066 ISO     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS     positive regulation of DNA binding GO:0043388 IDA     post-translational protein modification GO:0043687 IEA     NLRP3 inflammasome complex assembly GO:0044546 IMP     regulation of fat cell differentiation GO:0045598 IMP     negative regulation of fat cell differentiation GO:0045599 IMP     positive regulation of fatty acid biosynthetic process GO:0045723 IEA     positive regulation of fatty acid biosynthetic process GO:0045723 ISO     positive regulation of meiotic nuclear division GO:0045836 IMP     negative regulation of striated muscle tissue development GO:0045843 ISO     negative regulation of striated muscle tissue development GO:0045843 ISS     negative regulation of DNA-templated transcription GO:0045892 ISO     negative regulation of DNA-templated transcription GO:0045892 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     negative regulation of oligodendrocyte differentiation GO:0048715 ISO     cell division GO:0051301 IEA     meiotic cell cycle GO:0051321 IEA     regulation of cell cycle GO:0051726 ISO     regulation of cell cycle GO:0051726 ISS     positive regulation of cell division GO:0051781 IMP     positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 IMP     cellular response to caloric restriction GO:0061433 IDA     negative regulation of oligodendrocyte progenitor proliferation GO:0070446 ISO     negative regulation of oligodendrocyte progenitor proliferation GO:0070446 ISS     cellular response to hypoxia GO:0071456 ISO     cellular response to hypoxia GO:0071456 ISS     cellular response to epinephrine stimulus GO:0071872 IDA     tubulin deacetylation GO:0090042 IGI     tubulin deacetylation GO:0090042 IMP     tubulin deacetylation GO:0090042 ISO     regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 ISO     positive regulation of execution phase of apoptosis GO:1900119 IMP     positive regulation of oocyte maturation GO:1900195 IMP     negative regulation of NLRP3 inflammasome complex assembly GO:1900226 IMP     negative regulation of reactive oxygen species metabolic process GO:2000378 IMP Subcellular Localization     heterochromatin GO:0000792 ISO     heterochromatin GO:0000792 ISS     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     chromosome GO:0005694 ISO     chromosome GO:0005694 ISS     nucleolus GO:0005730 IEA     nucleolus GO:0005730 ISO     cytoplasm GO:0005737 HDA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     mitochondrion GO:0005739 IDA     centrosome GO:0005813 ISO     centrosome GO:0005813 ISS     centriole GO:0005814 ISO     centriole GO:0005814 ISS     spindle GO:0005819 ISO     spindle GO:0005819 ISS     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     microtubule GO:0005874 ISO     microtubule GO:0005874 ISS     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     growth cone GO:0030426 IEA     midbody GO:0030496 IDA     midbody GO:0030496 ISO     midbody GO:0030496 ISS     paranodal junction GO:0033010 IDA     paranodal junction GO:0033010 ISO     paranode region of axon GO:0033270 ISO     paranode region of axon GO:0033270 ISS     myelin sheath abaxonal region GO:0035748 ISO     perikaryon GO:0043204 IDA     perikaryon GO:0043204 ISO     myelin sheath GO:0043209 HDA     myelin sheath GO:0043209 IDA     myelin sheath GO:0043209 ISO     lateral loop GO:0043219 ISO     lateral loop GO:0043219 ISS     Schmidt-Lanterman incisure GO:0043220 IDA     Schmidt-Lanterman incisure GO:0043220 ISO     juxtaparanode region of axon GO:0044224 ISO     juxtaparanode region of axon GO:0044224 ISS     perinuclear region of cytoplasm GO:0048471 IDA     mitotic spindle GO:0072686 ISO     mitotic spindle GO:0072686 ISS     meiotic spindle GO:0072687 IDA     glial cell projection GO:0097386 ISO     glial cell projection GO:0097386 ISS     terminal loop GO:0097456 ISO     glutamatergic synapse GO:0098978 ISO