Gene description for SEPP1
Gene name selenoprotein P, plasma, 1
Gene symbol SEPP1
Other names/aliases SELP
SEPP
SeP
Species Homo sapiens
 Database cross references - SEPP1
ExoCarta ExoCarta_6414
Vesiclepedia VP_6414
Entrez Gene 6414
HGNC 10751
MIM 601484
UniProt P49908  
 SEPP1 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for SEPP1
Molecular Function
    selenium binding GO:0008430 IBA
Biological Process
    selenium compound metabolic process GO:0001887 IBA
    response to oxidative stress GO:0006979 TAS
    brain development GO:0007420 IEA
    locomotory behavior GO:0007626 IEA
    post-embryonic development GO:0009791 IEA
    sexual reproduction GO:0019953 IEA
    regulation of growth GO:0040008 IEA
Subcellular Localization
    extracellular region GO:0005576 IBA
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    platelet dense granule lumen GO:0031089 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SEPP1 in sEVs
1
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for SEPP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MEOX2  
Two-hybrid Homo sapiens
2 THRA  
Two-hybrid Homo sapiens
3 OBSL1 23363
Affinity Capture-MS Homo sapiens
4 EGFR 1956
PCA Homo sapiens
5 VHL  
Two-hybrid Homo sapiens
6 EP300 2033
Two-hybrid Homo sapiens
View the network image/svg+xml



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