Gene description for ATP10A
Gene name ATPase, class V, type 10A
Gene symbol ATP10A
Other names/aliases ATP10C
ATPVA
ATPVC
Species Homo sapiens
 Database cross references - ATP10A
ExoCarta ExoCarta_57194
Entrez Gene 57194
HGNC 13542
MIM 605855
UniProt O60312  
 ATP10A identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ATP10A
Molecular Function
    ATP binding GO:0005524 IEA
    magnesium ion binding GO:0000287 IEA
    phospholipid-translocating ATPase activity GO:0004012 NAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of cell shape GO:0008360 NAS
    phospholipid translocation GO:0045332 NAS
    transmembrane transport GO:0055085 TAS
    metabolic process GO:0008152 IEA
    ion transmembrane transport GO:0034220 TAS
    intracellular protein transport GO:0006886 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    endoplasmic reticulum GO:0005783 IDA
    integral component of membrane GO:0016021 NAS
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified ATP10A in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP10A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATP10A is involved
PathwayEvidenceSource
Ion transport by P-type ATPases TAS Reactome





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