Gene description for CEACAM6
Gene name carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
Gene symbol CEACAM6
Other names/aliases CD66c
CEAL
NCA
Species Homo sapiens
 Database cross references - CEACAM6
ExoCarta ExoCarta_4680
Vesiclepedia VP_4680
Entrez Gene 4680
HGNC 1818
MIM 163980
UniProt P40199  
 CEACAM6 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for CEACAM6
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 IPI
    protein heterodimerization activity GO:0046982 IDA
Biological Process
    apoptotic process GO:0006915 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IMP
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IBA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IMP
    positive regulation of cell population proliferation GO:0008284 IMP
    positive regulation of cell migration GO:0030335 IMP
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IMP
    positive regulation of endothelial cell-matrix adhesion via fibronectin GO:1904906 IMP
    negative regulation of anoikis GO:2000811 IMP
Subcellular Localization
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IC
    cell surface GO:0009986 IDA
    membrane GO:0016020 IDA
    apical plasma membrane GO:0016324 IDA
    azurophil granule membrane GO:0035577 TAS
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified CEACAM6 in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for CEACAM6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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