Gene description for ARR3
Gene name arrestin 3, retinal (X-arrestin)
Gene symbol ARR3
Other names/aliases ARRX
Species Homo sapiens
 Database cross references - ARR3
ExoCarta ExoCarta_407
Entrez Gene 407
HGNC 710
MIM 301770
UniProt P36575  
 ARR3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for ARR3
Molecular Function
    opsin binding GO:0002046 IEA
    protein binding GO:0005515 IPI
    phosphoprotein binding GO:0051219 IEA
Biological Process
    regulation of protein phosphorylation GO:0001932 IEA
    visual perception GO:0007601 IEA
    endocytosis GO:0006897 IEA
    signal transduction GO:0007165 IEA
Subcellular Localization
    synapse GO:0045202 IEA
    photoreceptor outer segment GO:0001750 IEA
    photoreceptor inner segment GO:0001917 IDA
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified ARR3 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for ARR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP1B1 162
Affinity Capture-Western Homo sapiens
2 RNASE6  
Two-hybrid Homo sapiens
3 GNMT  
Two-hybrid Homo sapiens
4 SRC 6714
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
5 AP3B1 8546
Affinity Capture-MS Homo sapiens
6 ZNF496  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 RHO  
Reconstituted Complex Homo sapiens
8 CSNK2A1 1457
Biochemical Activity Homo sapiens
9 DVL2 1856
Two-hybrid Homo sapiens
10 CAPNS1 826
Two-hybrid Homo sapiens
11 ARRB1 408
Affinity Capture-MS Homo sapiens
12 CSNK2A2 1459
Biochemical Activity Homo sapiens
13 PTAFR  
Invivo Homo sapiens
Invitro Homo sapiens
14 AP3B2  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ARR3 is involved
No pathways found





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