Gene description for IGFBP7
Gene name insulin-like growth factor binding protein 7
Gene symbol IGFBP7
Other names/aliases AGM
FSTL2
IBP-7
IGFBP-7
IGFBP-7v
IGFBPRP1
MAC25
PSF
RAMSVPS
TAF
Species Homo sapiens
 Database cross references - IGFBP7
ExoCarta ExoCarta_3490
Entrez Gene 3490
HGNC 5476
MIM 602867
UniProt Q16270  
 IGFBP7 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IGFBP7
Molecular Function
    insulin-like growth factor binding GO:0005520 IEA
    protein binding GO:0005515 IPI
Biological Process
    inner ear development GO:0048839 IEA
    negative regulation of cell proliferation GO:0008285 TAS
    response to heat GO:0009408 IEA
    response to cortisol GO:0051414 IEA
    cell adhesion GO:0007155 IDA
    response to retinoic acid GO:0032526 IEA
    regulation of steroid biosynthetic process GO:0050810 IEA
    embryo implantation GO:0007566 IEA
    regulation of cell growth GO:0001558 IEA
    cellular response to hormone stimulus GO:0032870 IEA
Subcellular Localization
    extracellular matrix GO:0031012 IDA
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified IGFBP7 in exosomes
1
Experiment ID 189
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IGFBP7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INS 3630
Invitro Homo sapiens
2 CHMP3 51652
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 VEGF  
Reconstituted Complex Homo sapiens
4 IGF1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
5 IGF2 3481
Reconstituted Complex Homo sapiens
6 INHBA 3624
Invitro Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which IGFBP7 is involved
PathwayEvidenceSource
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome





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