Gene description for TNFRSF21
Gene name tumor necrosis factor receptor superfamily, member 21
Gene symbol TNFRSF21
Other names/aliases BM-018
CD358
DR6
Species Homo sapiens
 Database cross references - TNFRSF21
ExoCarta ExoCarta_27242
Entrez Gene 27242
HGNC 13469
MIM 605732
UniProt O75509  
 TNFRSF21 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TNFRSF21
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of interleukin-10 secretion GO:2001180 ISS
    oligodendrocyte apoptotic process GO:0097252 ISS
    myelination GO:0042552 ISS
    regulation of oligodendrocyte differentiation GO:0048713 ISS
    negative regulation of interleukin-5 secretion GO:2000663 ISS
    cellular response to tumor necrosis factor GO:0071356 IDA
    negative regulation of myelination GO:0031642 IMP
    apoptotic process GO:0006915 IMP
    cellular lipid metabolic process GO:0044255 TAS
    humoral immune response GO:0006959 ISS
    negative regulation of B cell proliferation GO:0030889 ISS
    small molecule metabolic process GO:0044281 TAS
    neuron apoptotic process GO:0051402 ISS
    T cell receptor signaling pathway GO:0050852 ISS
    negative regulation of interleukin-13 secretion GO:2000666 ISS
    adaptive immune response GO:0002250 ISS
    negative regulation of T cell proliferation GO:0042130 ISS
    B cell apoptotic process GO:0001783 ISS
Subcellular Localization
    axon GO:0030424 IEA
    plasma membrane GO:0005886 TAS
    intrinsic component of plasma membrane GO:0031226 ISS
    integral component of plasma membrane GO:0005887 IDA
 Experiment description of studies that identified TNFRSF21 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TNFRSF21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRADD 8717
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which TNFRSF21 is involved
PathwayEvidenceSource
PPARA activates gene expression TAS Reactome





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