Gene description for ANKRD1
Gene name ankyrin repeat domain 1 (cardiac muscle)
Gene symbol ANKRD1
Other names/aliases ALRP
C-193
CARP
CVARP
MCARP
bA320F15.2
Species Homo sapiens
 Database cross references - ANKRD1
ExoCarta ExoCarta_27063
Entrez Gene 27063
HGNC 15819
MIM 609599
UniProt Q15327  
 ANKRD1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ANKRD1
Molecular Function
    RNA polymerase II transcription coactivator activity GO:0001105 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IDA
    histone deacetylase binding GO:0042826 IPI
    p53 binding GO:0002039 IPI
    R-SMAD binding GO:0070412 IPI
    RNA polymerase II transcription factor binding GO:0001085 IPI
    titin binding GO:0031432 IPI
    transcription corepressor activity GO:0003714 TAS
Biological Process
    cellular response to tumor necrosis factor GO:0071356 IDA
    response to muscle stretch GO:0035994 IMP
    small molecule metabolic process GO:0044281 TAS
    cellular response to hypoxia GO:0071456 IEA
    negative regulation of DNA biosynthetic process GO:2000279 IMP
    positive regulation of apoptotic process GO:0043065 IMP
    cellular response to interleukin-1 GO:0071347 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    cellular response to lipopolysaccharide GO:0071222 IDA
    skeletal muscle cell differentiation GO:0035914 IEA
    positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 IDA
    cellular response to drug GO:0035690 IEA
    positive regulation of protein secretion GO:0050714 IMP
    cardiac muscle tissue morphogenesis GO:0055008 IMP
    cellular lipid metabolic process GO:0044255 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    positive regulation of neuron projection development GO:0010976 IEA
    cellular response to mechanical stimulus GO:0071260 IDA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    sarcomere organization GO:0045214 NAS
    cellular response to organic cyclic compound GO:0071407 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    sarcomere GO:0030017 IBA
    transcription factor complex GO:0005667 IEA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IDA
    nucleolus GO:0005730 IDA
    I band GO:0031674 ISS
 Experiment description of studies that identified ANKRD1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ANKRD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MYPN 84665
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 TTN 7273
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ANKRD1 is involved
PathwayEvidenceSource
PPARA activates gene expression TAS Reactome





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