Gene description for ARL5A
Gene name ADP-ribosylation factor-like 5A
Gene symbol ARL5A
Other names/aliases ARFLP5
ARL5
Species Homo sapiens
 Database cross references - ARL5A
ExoCarta ExoCarta_26225
Vesiclepedia VP_26225
Entrez Gene 26225
HGNC 696
MIM 608960
UniProt Q9Y689  
 ARL5A identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ARL5A
Molecular Function
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IEA
Biological Process
    intracellular protein transport GO:0006886 IBA
    vesicle-mediated transport GO:0016192 IBA
    protein localization to Golgi membrane GO:1903292 IBA
    protein localization to Golgi membrane GO:1903292 IGI
Subcellular Localization
    cytoplasm GO:0005737 IBA
    trans-Golgi network GO:0005802 IBA
 Experiment description of studies that identified ARL5A in sEVs
1
Experiment ID 834
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ARL5A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 PHKA2 5256
Affinity Capture-MS Homo sapiens
3 CBX3 11335
Two-hybrid Homo sapiens
4 CBX1 10951
Two-hybrid Homo sapiens
5 ARL5B  
Affinity Capture-MS Homo sapiens
6 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
7 KPNA2 3838
Reconstituted Complex Homo sapiens
8 NEDD8-MDP1 100528064
Affinity Capture-MS Homo sapiens
9 CBX5 23468
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
10 S1PR2 9294
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ARL5A is involved
No pathways found





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