Gene description for Gstm1
Gene name glutathione S-transferase mu 1
Gene symbol Gstm1
Other names/aliases GSTA3
Species Rattus norvegicus
 Database cross references - Gstm1
ExoCarta ExoCarta_24423
Vesiclepedia VP_24423
Entrez Gene 24423
UniProt P04905  
 Gstm1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Gstm1
Molecular Function
    glutathione transferase activity GO:0004364 IBA
    glutathione transferase activity GO:0004364 IDA
    glutathione transferase activity GO:0004364 IEA
    glutathione transferase activity GO:0004364 ISO
    steroid binding GO:0005496 IPI
    nickel cation binding GO:0016151 IDA
    enzyme binding GO:0019899 ISO
    protein kinase binding GO:0019901 IPI
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    glutathione binding GO:0043295 IDA
    glutathione binding GO:0043295 ISO
Biological Process
    prostaglandin metabolic process GO:0006693 ISO
    prostaglandin metabolic process GO:0006693 ISS
    glutathione metabolic process GO:0006749 IBA
    glutathione metabolic process GO:0006749 IDA
    glutathione metabolic process GO:0006749 IMP
    glutathione metabolic process GO:0006749 ISO
    sensory perception of smell GO:0007608 IEA
    response to xenobiotic stimulus GO:0009410 IEP
    response to metal ion GO:0010038 IEP
    response to lead ion GO:0010288 IEP
    nitrobenzene metabolic process GO:0018916 ISO
    xenobiotic catabolic process GO:0042178 IDA
    xenobiotic catabolic process GO:0042178 ISO
    response to amino acid GO:0043200 IEP
    response to ethanol GO:0045471 IEP
    response to axon injury GO:0048678 IEP
    hepoxilin biosynthetic process GO:0051122 ISO
    hepoxilin biosynthetic process GO:0051122 ISS
    cellular detoxification of nitrogen compound GO:0070458 ISO
    cellular response to xenobiotic stimulus GO:0071466 ISO
    glutathione derivative biosynthetic process GO:1901687 ISO
    glutathione derivative biosynthetic process GO:1901687 ISS
Subcellular Localization
    extracellular region GO:0005576 IDA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    protein-containing complex GO:0032991 IDA
    intercellular bridge GO:0045171 ISO
 Experiment description of studies that identified Gstm1 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Gstm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
2 Gstm1 24423
Co-crystal Structure Rattus norvegicus
Co-crystal Structure Rattus norvegicus
View the network image/svg+xml
 Pathways in which Gstm1 is involved
PathwayEvidenceSource
Biological oxidations IEA Reactome
Glutathione conjugation IEA Reactome
Metabolism IEA Reactome
Phase II - Conjugation of compounds IEA Reactome





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