Gene description for Cdc6
Gene name cell division cycle 6
Gene symbol Cdc6
Other names/aliases CDC18L
Species Mus musculus
 Database cross references - Cdc6
ExoCarta ExoCarta_23834
Entrez Gene 23834
UniProt O89033  
 Cdc6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cdc6
Molecular Function
    ATP binding GO:0005524 IEA
    chromatin binding GO:0003682 IDA
    nucleotide binding GO:0000166 IEA
    kinase binding GO:0019900 ISO
Biological Process
    cell division GO:0051301 IEA
    regulation of mitotic metaphase/anaphase transition GO:0030071 ISO
    cell cycle GO:0007049 IEA
    positive regulation of chromosome segregation GO:0051984 ISO
    positive regulation of cytokinesis GO:0032467 ISO
    DNA replication GO:0006260 IEA
    mitotic nuclear division GO:0007067 IEA
Subcellular Localization
    spindle GO:0005819 IDA
    spindle pole GO:0000922 ISO
    cytoplasm GO:0005737 ISO
    Golgi apparatus GO:0005794 ISO
    nucleoplasm GO:0005654 ISO
    spindle midzone GO:0051233 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Cdc6 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cdc6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here