Gene description for MLYCD
Gene name malonyl-CoA decarboxylase
Gene symbol MLYCD
Other names/aliases MCD
Species Homo sapiens
 Database cross references - MLYCD
ExoCarta ExoCarta_23417
Vesiclepedia VP_23417
Entrez Gene 23417
HGNC 7150
MIM 606761
UniProt O95822  
 MLYCD identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MLYCD
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    malonyl-CoA decarboxylase activity GO:0050080 IBA
    malonyl-CoA decarboxylase activity GO:0050080 IDA
    malonyl-CoA decarboxylase activity GO:0050080 TAS
Biological Process
    response to ischemia GO:0002931 ISS
    acetyl-CoA biosynthetic process GO:0006085 IBA
    acetyl-CoA biosynthetic process GO:0006085 IDA
    acetyl-CoA biosynthetic process GO:0006085 IEA
    fatty acid biosynthetic process GO:0006633 IBA
    fatty acid biosynthetic process GO:0006633 IDA
    acyl-CoA metabolic process GO:0006637 TAS
    response to nutrient GO:0007584 IEA
    regulation of glucose metabolic process GO:0010906 IMP
    fatty acid oxidation GO:0019395 IEA
    regulation of fatty acid beta-oxidation GO:0031998 IEA
    positive regulation of fatty acid oxidation GO:0046321 IMP
    malonyl-CoA catabolic process GO:2001294 IBA
    malonyl-CoA catabolic process GO:2001294 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 ISS
    peroxisome GO:0005777 IDA
    peroxisomal matrix GO:0005782 IBA
    peroxisomal matrix GO:0005782 ISS
    peroxisomal matrix GO:0005782 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified MLYCD in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MLYCD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KDF1  
Affinity Capture-MS Homo sapiens
2 SNTG1  
Affinity Capture-MS Homo sapiens
3 RBM5  
Affinity Capture-MS Homo sapiens
4 FGF11  
Affinity Capture-MS Homo sapiens
5 SNX9 51429
Affinity Capture-MS Homo sapiens
6 PCDHGA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 COQ6 51004
Affinity Capture-MS Homo sapiens
8 IL25  
Affinity Capture-MS Homo sapiens
9 CCL15  
Affinity Capture-MS Homo sapiens
10 TMEM88  
Affinity Capture-MS Homo sapiens
11 FYCO1 79443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PCDHA3  
Affinity Capture-MS Homo sapiens
13 PARK2  
Affinity Capture-MS Homo sapiens
14 TMEM159 57146
Affinity Capture-MS Homo sapiens
15 PCDHA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PCDHA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PLD3 23646
Co-fractionation Homo sapiens
18 UBALD1  
Two-hybrid Homo sapiens
19 SOHLH1  
Affinity Capture-MS Homo sapiens
20 PCDHA12  
Affinity Capture-MS Homo sapiens
21 PEX5 5830
Protein-peptide Homo sapiens
22 C1orf158  
Affinity Capture-MS Homo sapiens
23 SPTY2D1  
Affinity Capture-MS Homo sapiens
24 PCDHGC5  
Affinity Capture-MS Homo sapiens
25 ADCK1  
Affinity Capture-MS Homo sapiens
26 DACT2  
Affinity Capture-MS Homo sapiens
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