Gene description for PLCL2
Gene name phospholipase C-like 2
Gene symbol PLCL2
Other names/aliases PLCE2
Species Homo sapiens
 Database cross references - PLCL2
ExoCarta ExoCarta_23228
Entrez Gene 23228
HGNC 9064
MIM 614276
UniProt Q9UPR0  
 PLCL2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PLCL2
Molecular Function
    signal transducer activity GO:0004871 IEA
    GABA receptor binding GO:0050811 IDA
    phosphatidylinositol phospholipase C activity GO:0004435 IEA
Biological Process
    B-1a B cell differentiation GO:0002337 IEA
    regulation of peptidyl-serine phosphorylation GO:0033135 IEA
    gamma-aminobutyric acid signaling pathway GO:0007214 IEA
    lipid metabolic process GO:0006629 IEA
    regulation of synaptic transmission, GABAergic GO:0032228 IEA
    B cell proliferation involved in immune response GO:0002322 IEA
    negative regulation of B cell receptor signaling pathway GO:0050859 IEA
    positive regulation of receptor binding GO:1900122 IEA
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified PLCL2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PLCL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP1CA 5499
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLCL2 is involved
No pathways found





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