Gene description for NLGN4Y
Gene name neuroligin 4, Y-linked
Gene symbol NLGN4Y
Other names/aliases -
Species Homo sapiens
 Database cross references - NLGN4Y
ExoCarta ExoCarta_22829
Entrez Gene 22829
HGNC 15529
MIM 400028
UniProt Q8NFZ3  
 NLGN4Y identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NLGN4Y
Molecular Function
    protein binding GO:0005515 IPI
    carboxylic ester hydrolase activity GO:0052689 IBA
    receptor activity GO:0004872 IBA
    cell adhesion molecule binding GO:0050839 TAS
    scaffold protein binding GO:0097110 IPI
    neurexin family protein binding GO:0042043 IBA
Biological Process
    vocalization behavior GO:0071625 IMP
    learning GO:0007612 IMP
    neuron cell-cell adhesion GO:0007158 TAS
    synapse assembly GO:0007416 IBA
    social behavior GO:0035176 IMP
    regulation of synaptic transmission GO:0050804 IBA
    metabolic process GO:0008152 IBA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IBA
    cell surface GO:0009986 IBA
    postsynaptic density GO:0014069 IEA
    cell junction GO:0030054 IEA
    extracellular space GO:0005615 IBA
    synapse GO:0045202 IBA
    postsynaptic membrane GO:0045211 IEA
 Experiment description of studies that identified NLGN4Y in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NLGN4Y
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NLGN4Y is involved
No pathways found





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