Gene description for Aph1a
Gene name	anterior pharynx defective 1a homolog (C. elegans)
Gene symbol	Aph1a
Other names/aliases	6530402N02Rik APH-1a
Species	Mus musculus
Database cross references - Aph1a
ExoCarta	ExoCarta_226548
Vesiclepedia	VP_226548
Entrez Gene	226548
UniProt	Q8BVF7
Aph1a identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Aph1a

Molecular Function     protein binding GO:0005515 IPI     peptidase activity GO:0008233 ISA     enzyme binding GO:0019899 IPI     protein-macromolecule adaptor activity GO:0030674 IBA     protein-macromolecule adaptor activity GO:0030674 IEA     protein-macromolecule adaptor activity GO:0030674 ISO     endopeptidase activator activity GO:0061133 IMP     endopeptidase activator activity GO:0061133 ISO Biological Process     metanephros development GO:0001656 IMP     membrane protein ectodomain proteolysis GO:0006509 ISO     membrane protein ectodomain proteolysis GO:0006509 ISS     Notch signaling pathway GO:0007219 IBA     Notch signaling pathway GO:0007219 IEA     Notch receptor processing GO:0007220 IBA     Notch receptor processing GO:0007220 IMP     Notch receptor processing GO:0007220 ISO     Notch receptor processing GO:0007220 NAS     positive regulation of endopeptidase activity GO:0010950 IMP     positive regulation of endopeptidase activity GO:0010950 ISO     protein processing GO:0016485 IBA     protein processing GO:0016485 ISA     protein processing GO:0016485 ISO     protein processing GO:0016485 ISS     membrane protein intracellular domain proteolysis GO:0031293 ISO     membrane protein intracellular domain proteolysis GO:0031293 ISS     amyloid-beta formation GO:0034205 IEA     amyloid-beta formation GO:0034205 ISO     amyloid precursor protein metabolic process GO:0042982 ISO     amyloid precursor protein catabolic process GO:0042987 ISO     amyloid precursor protein catabolic process GO:0042987 ISS Subcellular Localization     Golgi membrane GO:0000139 NAS     early endosome GO:0005769 IEA     early endosome GO:0005769 ISO     endoplasmic reticulum GO:0005783 IBA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum GO:0005783 ISS     endoplasmic reticulum GO:0005783 NAS     endoplasmic reticulum membrane GO:0005789 NAS     Golgi apparatus GO:0005794 ISO     Golgi apparatus GO:0005794 ISS     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     synaptic vesicle GO:0008021 IEA     synaptic vesicle GO:0008021 ISO     membrane GO:0016020 ISA     membrane GO:0016020 ISO     Golgi cisterna membrane GO:0032580 IEA     presynaptic membrane GO:0042734 IEA     presynaptic membrane GO:0042734 ISO     gamma-secretase complex GO:0070765 IBA     gamma-secretase complex GO:0070765 ISO     gamma-secretase complex GO:0070765 ISS     synaptic membrane GO:0097060 ISO