Gene description for Baz1b
Gene name bromodomain adjacent to zinc finger domain, 1B
Gene symbol Baz1b
Other names/aliases C87820
WSTF
Wbscr9
Species Mus musculus
 Database cross references - Baz1b
ExoCarta ExoCarta_22385
Vesiclepedia VP_22385
Entrez Gene 22385
UniProt Q9Z277  
 Baz1b identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Baz1b
Molecular Function
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone kinase activity GO:0035173 IBA
    histone H3Y41 kinase activity GO:0035401 IEA
    histone binding GO:0042393 IBA
    histone binding GO:0042393 IPI
    metal ion binding GO:0046872 IEA
    histone H2AXY142 kinase activity GO:0140801 ISO
    histone H2AXY142 kinase activity GO:0140801 ISS
Biological Process
    chromatin organization GO:0006325 IDA
    chromatin remodeling GO:0006338 IBA
    chromatin remodeling GO:0006338 IDA
    chromatin remodeling GO:0006338 IDA
    chromatin remodeling GO:0006338 ISO
    chromatin remodeling GO:0006338 NAS
    DNA damage response GO:0006974 IBA
    DNA damage response GO:0006974 ISO
    DNA damage response GO:0006974 ISS
    DNA damage response GO:0006974 NAS
    post-translational protein modification GO:0043687 ISO
    post-translational protein modification GO:0043687 ISS
    positive regulation of transcription by RNA polymerase I GO:0045943 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    positive regulation of transcription by RNA polymerase III GO:0045945 ISO
    negative regulation of mitotic chromosome condensation GO:1905213 ISO
Subcellular Localization
    condensed chromosome GO:0000793 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    pericentric heterochromatin GO:0005721 IDA
    nucleolus GO:0005730 NAS
    nuclear replication fork GO:0043596 IEA
    nuclear replication fork GO:0043596 ISO
    WICH complex GO:0090535 IBA
    WICH complex GO:0090535 ISO
    B-WICH complex GO:0110016 ISO
 Experiment description of studies that identified Baz1b in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Baz1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Arid1a  
Co-fractionation Mus musculus
2 Smarca5 93762
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Cdt1  
Co-fractionation Mus musculus
5 Atad5  
Co-fractionation Mus musculus
6 Smarca2  
Co-fractionation Mus musculus
7 Cul3  
Affinity Capture-MS Mus musculus
8 Acpp  
Co-fractionation Mus musculus
9 Smarca1  
Co-fractionation Mus musculus
10 Pappa  
Co-fractionation Mus musculus
11 Smarcc2  
Co-fractionation Mus musculus
12 Supt16 114741
Co-fractionation Mus musculus
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