Gene description for F2R
Gene name	coagulation factor II (thrombin) receptor
Gene symbol	F2R
Other names/aliases	CF2R HTR PAR-1 PAR1 TR
Species	Homo sapiens
Database cross references - F2R
ExoCarta	ExoCarta_2149
Entrez Gene	2149
HGNC	3537
MIM	187930
UniProt	P25116
F2R identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for F2R

Molecular Function     G-protein alpha-subunit binding GO:0001965 ISS     G-protein beta-subunit binding GO:0031681 ISS     G-protein coupled receptor activity GO:0004930 TAS     thrombin receptor activity GO:0015057 IDA     protein binding GO:0005515 IPI     receptor binding GO:0005102 IPI Biological Process     negative regulation of glomerular filtration GO:0003105 ISS     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA     positive regulation of interleukin-6 secretion GO:2000778 IDA     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP     regulation of sensory perception of pain GO:0051930 ISS     negative regulation of renin secretion into blood stream GO:1900134 ISS     positive regulation of MAPK cascade GO:0043410 IDA     positive regulation of vasoconstriction GO:0045907 ISS     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISS     regulation of blood coagulation GO:0030193 IDA     positive regulation of transcription, DNA-templated GO:0045893 IDA     positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IDA     anatomical structure morphogenesis GO:0009653 TAS     positive regulation of calcium ion transport GO:0051928 ISS     positive regulation of smooth muscle contraction GO:0045987 ISS     positive regulation of blood coagulation GO:0030194 IDA     protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 ISS     positive regulation of cell migration GO:0030335 IMP     STAT protein import into nucleus GO:0007262 IDA     platelet dense granule organization GO:0060155 IC     response to wounding GO:0009611 IDA     release of sequestered calcium ion into cytosol GO:0051209 ISS     G-protein coupled receptor signaling pathway GO:0007186 ISS     establishment of synaptic specificity at neuromuscular junction GO:0007529 ISS     positive regulation of cell proliferation GO:0008284 ISS     tyrosine phosphorylation of STAT protein GO:0007260 IDA     negative regulation of neuron apoptotic process GO:0043524 ISS     activation of MAPKK activity GO:0000186 ISS     positive regulation of interleukin-8 secretion GO:2000484 IDA     response to lipopolysaccharide GO:0032496 ISS     inflammatory response GO:0006954 ISS     positive regulation of Rho protein signal transduction GO:0035025 ISS     positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 ISS     positive regulation of collagen biosynthetic process GO:0032967 IDA     thrombin receptor signaling pathway GO:0070493 IEA     blood coagulation GO:0007596 TAS     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     connective tissue replacement involved in inflammatory response wound healing GO:0002248 IDA     regulation of interleukin-1 beta production GO:0032651 ISS     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IDA     positive regulation of JAK-STAT cascade GO:0046427 IDA     homeostasis of number of cells within a tissue GO:0048873 ISS     phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IDA     platelet activation GO:0030168 TAS     positive regulation of cytosolic calcium ion concentration GO:0007204 ISS     negative regulation of cell proliferation GO:0008285 IDA Subcellular Localization     early endosome GO:0005769 IDA     caveola GO:0005901 IDA     extracellular region GO:0005576 TAS     Golgi apparatus GO:0005794 TAS     neuromuscular junction GO:0031594 ISS     platelet dense tubular network GO:0031094 IDA     late endosome GO:0005770 IDA     cytosol GO:0005829 ISS     postsynaptic membrane GO:0045211 ISS     integral component of plasma membrane GO:0005887 TAS     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA