Gene description for ELANE
Gene name	elastase, neutrophil expressed
Gene symbol	ELANE
Other names/aliases	ELA2 GE HLE HNE NE PMN-E SCN1
Species	Homo sapiens
Database cross references - ELANE
ExoCarta	ExoCarta_1991
Vesiclepedia	VP_1991
Entrez Gene	1991
HGNC	3309
MIM	130130
UniProt	P08246
ELANE identified in sEVs derived from the following tissue/cell type
Thymus	23844026
Urine	19056867

Gene ontology annotations for ELANE

Molecular Function     protease binding GO:0002020 IPI     transcription corepressor activity GO:0003714 IMP     endopeptidase activity GO:0004175 IDA     serine-type endopeptidase activity GO:0004252 EXP     serine-type endopeptidase activity GO:0004252 IBA     serine-type endopeptidase activity GO:0004252 IDA     serine-type endopeptidase activity GO:0004252 TAS     protein binding GO:0005515 IPI     heparin binding GO:0008201 IDA     peptidase activity GO:0008233 IDA     cytokine binding GO:0019955 IPI Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     response to yeast GO:0001878 IEA     acute inflammatory response to antigenic stimulus GO:0002438 IBA     leukocyte migration involved in inflammatory response GO:0002523 IEA     biosynthetic process of antibacterial peptides active against Gram-negative bacteria GO:0002812 IDA     proteolysis GO:0006508 IBA     proteolysis GO:0006508 IDA     proteolysis GO:0006508 IDA     intracellular calcium ion homeostasis GO:0006874 NAS     phagocytosis GO:0006909 IBA     response to UV GO:0009411 IDA     extracellular matrix disassembly GO:0022617 TAS     protein catabolic process GO:0030163 NAS     response to lipopolysaccharide GO:0032496 IEA     negative regulation of chemokine production GO:0032682 IDA     negative regulation of interleukin-8 production GO:0032717 IDA     positive regulation of interleukin-8 production GO:0032757 IDA     defense response to bacterium GO:0042742 IDA     positive regulation of MAP kinase activity GO:0043406 NAS     positive regulation of smooth muscle cell proliferation GO:0048661 IDA     negative regulation of inflammatory response GO:0050728 NAS     positive regulation of immune response GO:0050778 IEA     negative regulation of chemotaxis GO:0050922 NAS     pyroptotic inflammatory response GO:0070269 TAS     neutrophil-mediated killing of gram-negative bacterium GO:0070945 IDA     neutrophil-mediated killing of fungus GO:0070947 IEA     positive regulation of leukocyte tethering or rolling GO:1903238 IEA Subcellular Localization     extracellular region GO:0005576 NAS     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     cell surface GO:0009986 IDA     transcription repressor complex GO:0017053 IDA     secretory granule GO:0030141 IDA     azurophil granule lumen GO:0035578 TAS     specific granule lumen GO:0035580 TAS     phagocytic vesicle GO:0045335 IEA     collagen-containing extracellular matrix GO:0062023 HDA     extracellular exosome GO:0070062 HDA