Gene description for Rab10
Gene name RAB10, member RAS oncogene family
Gene symbol Rab10
Other names/aliases AW107754
Species Mus musculus
 Database cross references - Rab10
ExoCarta ExoCarta_19325
Entrez Gene 19325
UniProt P61027  
 Rab10 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mov neuroglial cells 15210972    
 Gene ontology annotations for Rab10
Molecular Function
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    GDP binding GO:0019003 ISO
    GTP binding GO:0005525 ISO
    myosin V binding GO:0031489 ISO
    GTPase activity GO:0003924 ISO
Biological Process
    establishment of protein localization to membrane GO:0090150 ISO
    intracellular protein transport GO:0006886 TAS
    vesicle docking involved in exocytosis GO:0006904 IBA
    antigen processing and presentation GO:0019882 ISO
    cellular response to insulin stimulus GO:0032869 IMP
    protein localization to plasma membrane GO:0072659 IMP
    protein transport GO:0015031 IEA
    establishment of neuroblast polarity GO:0045200 ISO
    transport GO:0006810 IEA
    establishment of protein localization to endoplasmic reticulum membrane GO:0097051 ISO
    metabolic process GO:0008152 ISO
    Golgi to plasma membrane transport GO:0006893 ISO
    Rab protein signal transduction GO:0032482 IBA
    protein secretion GO:0009306 IBA
    vesicle-mediated transport GO:0016192 IMP
    endosomal transport GO:0016197 ISO
    regulation of exocytosis GO:0017157 IBA
    small GTPase mediated signal transduction GO:0007264 IEA
    endoplasmic reticulum tubular network organization GO:0071786 ISO
    axonogenesis GO:0007409 ISO
Subcellular Localization
    primary cilium GO:0072372 ISO
    endoplasmic reticulum tubular network GO:0071782 ISO
    endoplasmic reticulum GO:0005783 IEA
    insulin-responsive compartment GO:0032593 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    plasma membrane GO:0005886 ISO
    trans-Golgi network GO:0005802 ISO
    intracellular GO:0005622 TAS
    cytoplasmic vesicle GO:0031410 IEA
    cell projection GO:0042995 IEA
    recycling endosome GO:0055037 ISO
    endosome membrane GO:0010008 IBA
    focal adhesion GO:0005925 ISO
    endosome GO:0005768 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    Golgi apparatus GO:0005794 ISO
    cell GO:0005623 TAS
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Rab10 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 39
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|HSC70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Rab10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab10 is involved
PathwayEvidenceSource
Translocation of GLUT4 to the plasma membrane IEA Reactome





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