Gene description for DPYS
Gene name dihydropyrimidinase
Gene symbol DPYS
Other names/aliases DHP
DHPase
Species Homo sapiens
 Database cross references - DPYS
ExoCarta ExoCarta_1807
Entrez Gene 1807
HGNC 3013
MIM 613326
UniProt Q14117  
 DPYS identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Urine 19056867    
 Gene ontology annotations for DPYS
Molecular Function
    thymine binding GO:0002059 IEA
    dihydropyrimidinase activity GO:0004157 TAS
    amino acid binding GO:0016597 IEA
    zinc ion binding GO:0008270 NAS
    uracil binding GO:0002058 IEA
    phosphoprotein binding GO:0051219 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    pyrimidine nucleoside catabolic process GO:0046135 TAS
    thymine catabolic process GO:0006210 ISS
    pyrimidine nucleobase metabolic process GO:0006206 TAS
    pyrimidine nucleobase catabolic process GO:0006208 IDA
    protein homotetramerization GO:0051289 ISS
    beta-alanine metabolic process GO:0019482 IEA
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    uracil catabolic process GO:0006212 IMP
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified DPYS in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DPYS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPYSL5  
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DPYS is involved
PathwayEvidenceSource
Pyrimidine catabolism TAS Reactome





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