Gene description for Krt19
Gene name keratin 19
Gene symbol Krt19
Other names/aliases AI663979
EndoC
K19
Krt-1.19
Krt1-19
Species Mus musculus
 Database cross references - Krt19
ExoCarta ExoCarta_16669
Vesiclepedia VP_16669
Entrez Gene 16669
UniProt P19001  
 Krt19 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt19
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of muscle GO:0008307 IEA
    structural constituent of muscle GO:0008307 ISO
    protein-containing complex binding GO:0044877 ISO
Biological Process
    Notch signaling pathway GO:0007219 IDA
    epithelial cell differentiation GO:0030855 IBA
    response to estrogen GO:0043627 IEA
    intermediate filament organization GO:0045109 IBA
    sarcomere organization GO:0045214 IEA
    sarcomere organization GO:0045214 ISO
    cell differentiation involved in embryonic placenta development GO:0060706 IGI
Subcellular Localization
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 IEA
    plasma membrane GO:0005886 ISO
    dystrophin-associated glycoprotein complex GO:0016010 ISO
    apicolateral plasma membrane GO:0016327 IDA
    Z disc GO:0030018 IDA
    sarcolemma GO:0042383 IDA
    costamere GO:0043034 IEA
    costamere GO:0043034 ISO
    cell periphery GO:0071944 ISO
    terminal web GO:1990357 IDA
 Experiment description of studies that identified Krt19 in sEVs
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rad51b  
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Atxn1  
Affinity Capture-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Sae1 56459
Co-fractionation Mus musculus
6 Fstl1  
Co-fractionation Mus musculus
7 Fkbp7  
Co-fractionation Mus musculus
8 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Krt19 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the cornified envelope IEA Reactome
Keratinization IEA Reactome





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