Gene description for ATP8B3
Gene name ATPase, aminophospholipid transporter, class I, type 8B, member 3
Gene symbol ATP8B3
Other names/aliases ATPIK
Species Homo sapiens
 Database cross references - ATP8B3
ExoCarta ExoCarta_148229
Entrez Gene 148229
HGNC 13535
MIM 605866
UniProt O60423  
 ATP8B3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ATP8B3
Molecular Function
    magnesium ion binding GO:0000287 IEA
    ATP binding GO:0005524 IEA
    phospholipid-translocating ATPase activity GO:0004012 IBA
Biological Process
    binding of sperm to zona pellucida GO:0007339 IEA
    metabolic process GO:0008152 IEA
    Golgi organization GO:0007030 IBA
    phospholipid translocation GO:0045332 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    acrosomal membrane GO:0002080 IEA
    Golgi apparatus GO:0005794 IBA
    plasma membrane GO:0005886 IBA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified ATP8B3 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ATP8B3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATP8B3 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases TAS Reactome





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