Gene description for CR2
Gene name complement component (3d/Epstein Barr virus) receptor 2
Gene symbol CR2
Other names/aliases C3DR
CD21
CR
CVID7
SLEB9
Species Homo sapiens
 Database cross references - CR2
ExoCarta ExoCarta_1380
Entrez Gene 1380
HGNC 2336
MIM 120650
UniProt P20023  
 CR2 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for CR2
Molecular Function
    complement receptor activity GO:0004875 NAS
    complement binding GO:0001848 IDA
    DNA binding GO:0003677 IDA
    transmembrane signaling receptor activity GO:0004888 NAS
    protein homodimerization activity GO:0042803 IDA
Biological Process
    immune response GO:0006955 NAS
    complement receptor mediated signaling pathway GO:0002430 IEA
    complement activation, classical pathway GO:0006958 IEA
    B cell proliferation GO:0042100 IDA
    innate immune response GO:0045087 IEA
    B cell differentiation GO:0030183 IDA
Subcellular Localization
    integral component of membrane GO:0016021 NAS
    receptor complex GO:0043235 IDA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 NAS
    external side of plasma membrane GO:0009897 IEA
 Experiment description of studies that identified CR2 in exosomes
1
Experiment ID 80
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 81
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for CR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFITM1 8519
Affinity Capture-Western Homo sapiens
2 CD81 975
Affinity Capture-Western Homo sapiens
3 C3 718
Invivo Homo sapiens
4 IFNA1  
Invivo Homo sapiens
5 CD19 930
Affinity Capture-Western Homo sapiens
6 FCER2 2208
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
7 ANXA6 309
Invitro Homo sapiens
8 CR1 1378
Invivo Homo sapiens
9 TP53  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CR2 is involved
No pathways found





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