Gene description for Cd36
Gene name	CD36 antigen
Gene symbol	Cd36
Other names/aliases	FAT GPIV Scarb3
Species	Mus musculus
Database cross references - Cd36
ExoCarta	ExoCarta_12491
Vesiclepedia	VP_12491
Entrez Gene	12491
UniProt	Q08857
Cd36 identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for Cd36

Molecular Function     amyloid-beta binding GO:0001540 IEA     amyloid-beta binding GO:0001540 ISO     low-density lipoprotein particle receptor activity GO:0005041 IBA     low-density lipoprotein particle receptor activity GO:0005041 IMP     low-density lipoprotein particle receptor activity GO:0005041 ISO     scavenger receptor activity GO:0005044 IBA     scavenger receptor activity GO:0005044 IEA     scavenger receptor activity GO:0005044 ISO     long-chain fatty acid transmembrane transporter activity GO:0005324 ISO     protein binding GO:0005515 IPI     high-density lipoprotein particle binding GO:0008035 IDA     lipid binding GO:0008289 ISO     lipid binding GO:0008289 ISS     short-chain fatty acid transmembrane transporter activity GO:0015636 IEA     short-chain fatty acid transmembrane transporter activity GO:0015636 ISO     low-density lipoprotein particle binding GO:0030169 IBA     low-density lipoprotein particle binding GO:0030169 IMP     low-density lipoprotein particle binding GO:0030169 ISO     Toll-like receptor binding GO:0035325 IEA     Toll-like receptor binding GO:0035325 ISO     cargo receptor activity GO:0038024 ISO     protein-containing complex binding GO:0044877 ISO     transforming growth factor beta binding GO:0050431 ISO     thrombospondin receptor activity GO:0070053 IEA     thrombospondin receptor activity GO:0070053 ISO     oleic acid binding GO:0070538 ISO     lipoteichoic acid immune receptor activity GO:0070892 IMP     lipoprotein particle binding GO:0071813 ISO     oxidised low-density lipoprotein particle receptor activity GO:0150025 IEA     oxidised low-density lipoprotein particle receptor activity GO:0150025 ISO     oleate transmembrane transporter activity GO:1901480 IEA     oleate transmembrane transporter activity GO:1901480 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     MAPK cascade GO:0000165 IMP     positive regulation of cell-matrix adhesion GO:0001954 IEA     positive regulation of cell-matrix adhesion GO:0001954 ISO     receptor-mediated endocytosis GO:0006898 IBA     receptor-mediated endocytosis GO:0006898 ISO     phagocytosis, recognition GO:0006910 IDA     cell adhesion GO:0007155 IEA     cell surface receptor signaling pathway GO:0007166 IDA     positive regulation of cytosolic calcium ion concentration GO:0007204 IDA     response to bacterium GO:0009617 IEP     positive regulation of gene expression GO:0010628 IMP     negative regulation of gene expression GO:0010629 IMP     positive regulation of macrophage derived foam cell differentiation GO:0010744 IMP     positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO     positive regulation of cholesterol storage GO:0010886 IMP     macrophage cytokine production GO:0010934 IMP     fatty acid transport GO:0015908 ISO     long-chain fatty acid transport GO:0015909 ISO     long-chain fatty acid import across plasma membrane GO:0015911 IEA     long-chain fatty acid import across plasma membrane GO:0015911 ISO     short-chain fatty acid transport GO:0015912 IEA     short-chain fatty acid transport GO:0015912 ISO     negative regulation of angiogenesis GO:0016525 IMP     negative regulation of angiogenesis GO:0016525 ISO     lipid storage GO:0019915 IBA     lipid storage GO:0019915 IMP     lipid storage GO:0019915 ISO     cGMP-mediated signaling GO:0019934 ISO     positive regulation of blood coagulation GO:0030194 IMP     intestinal cholesterol absorption GO:0030299 IMP     cholesterol transport GO:0030301 IMP     receptor internalization GO:0031623 IDA     interleukin-12 production GO:0032615 IMP     interleukin-6 production GO:0032635 IMP     tumor necrosis factor production GO:0032640 IMP     positive regulation of interleukin-1 beta production GO:0032731 IDA     positive regulation of interleukin-12 production GO:0032735 IMP     positive regulation of interleukin-6 production GO:0032755 IMP     positive regulation of tumor necrosis factor production GO:0032760 IMP     response to lipid GO:0033993 IDA     regulation of toll-like receptor signaling pathway GO:0034121 IEA     regulation of toll-like receptor signaling pathway GO:0034121 ISO     triglyceride transport GO:0034197 IMP     plasma lipoprotein particle clearance GO:0034381 IMP     low-density lipoprotein particle clearance GO:0034383 IBA     low-density lipoprotein particle clearance GO:0034383 IMP     low-density lipoprotein particle clearance GO:0034383 ISO     cellular response to oxidative stress GO:0034599 IMP     response to stilbenoid GO:0035634 IEP     nitric oxide-cGMP-mediated signaling GO:0038060 IEA     nitric oxide-cGMP-mediated signaling GO:0038060 ISO     negative regulation of protein import into nucleus GO:0042308 IMP     lipoprotein transport GO:0042953 IBA     lipoprotein transport GO:0042953 IMP     lipoprotein transport GO:0042953 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     regulation of protein-containing complex assembly GO:0043254 ISO     apoptotic cell clearance GO:0043277 IMP     positive regulation of MAPK cascade GO:0043410 IMP     long-chain fatty acid import into cell GO:0044539 IBA     long-chain fatty acid import into cell GO:0044539 IMP     long-chain fatty acid import into cell GO:0044539 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 IGI     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     defense response to Gram-positive bacterium GO:0050830 IMP     intestinal absorption GO:0050892 IMP     sensory perception of taste GO:0050909 IDA     low-density lipoprotein particle mediated signaling GO:0055096 IDA     positive regulation of phagocytosis, engulfment GO:0060100 IDA     positive regulation of phagocytosis, engulfment GO:0060100 IMP     positive regulation of macrophage cytokine production GO:0060907 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     cholesterol import GO:0070508 IMP     response to fatty acid GO:0070542 IDA     response to fatty acid GO:0070542 IMP     response to linoleic acid GO:0070543 IDA     cellular response to bacterial lipopeptide GO:0071221 IMP     cellular response to lipopolysaccharide GO:0071222 IMP     cellular response to lipoteichoic acid GO:0071223 IDA     cellular response to lipoteichoic acid GO:0071223 IMP     cellular response to low-density lipoprotein particle stimulus GO:0071404 IDA     cellular response to hydroperoxide GO:0071447 IMP     cellular response to diacyl bacterial lipopeptide GO:0071726 ISO     cellular response to diacyl bacterial lipopeptide GO:0071726 ISS     energy homeostasis GO:0097009 IMP     regulation of action potential GO:0098900 IMP     positive regulation of cold-induced thermogenesis GO:0120162 IMP     cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 IEA     cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 ISO     oxidised low-density lipoprotein particle clearance GO:0150024 IEA     oxidised low-density lipoprotein particle clearance GO:0150024 ISO     amyloid-beta clearance by cellular catabolic process GO:0150094 IBA     amyloid-beta clearance by cellular catabolic process GO:0150094 IEA     amyloid-beta clearance by cellular catabolic process GO:0150094 ISO     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IDA     positive regulation of reactive oxygen species biosynthetic process GO:1903428 IMP     cellular response to amyloid-beta GO:1904646 IEA     cellular response to amyloid-beta GO:1904646 ISO     amyloid fibril formation GO:1990000 IDA     lipid transport across blood-brain barrier GO:1990379 IEA     lipid transport across blood-brain barrier GO:1990379 ISO     regulation of removal of superoxide radicals GO:2000121 IMP     positive regulation of blood microparticle formation GO:2000334 IMP     positive regulation of reactive oxygen species metabolic process GO:2000379 IMP Subcellular Localization     Golgi apparatus GO:0005794 IDA     Golgi apparatus GO:0005794 ISO     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     caveola GO:0005901 IBA     caveola GO:0005901 ISO     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 IBA     cell surface GO:0009986 ISO     cell surface GO:0009986 ISS     membrane GO:0016020 IDA     apical plasma membrane GO:0016324 IEA     brush border membrane GO:0031526 IDA     brush border membrane GO:0031526 ISO     protein-containing complex GO:0032991 ISO     sarcolemma GO:0042383 ISO     receptor complex GO:0043235 IEA     receptor complex GO:0043235 ISO     membrane raft GO:0045121 IDA     membrane raft GO:0045121 ISO     apical part of cell GO:0045177 IDA     apical part of cell GO:0045177 ISO     cell periphery GO:0071944 ISO