Gene description for Aldh2
Gene name aldehyde dehydrogenase 2, mitochondrial
Gene symbol Aldh2
Other names/aliases AHD-M1
ALDH-E2
ALDHI
Ahd-5
Ahd5
Species Mus musculus
 Database cross references - Aldh2
ExoCarta ExoCarta_11669
Vesiclepedia VP_11669
Entrez Gene 11669
UniProt P47738  
 Aldh2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aldh2
Molecular Function
    aldehyde dehydrogenase (NAD+) activity GO:0004029 IBA
    aldehyde dehydrogenase (NAD+) activity GO:0004029 ISO
    aldehyde dehydrogenase (NAD+) activity GO:0004029 ISS
    protein binding GO:0005515 IPI
    phenylacetaldehyde dehydrogenase (NAD+) activity GO:0008957 ISS
    identical protein binding GO:0042802 ISO
    NAD binding GO:0051287 ISS
    NADH binding GO:0070404 ISO
    carboxylesterase activity GO:0106435 ISO
    carboxylesterase activity GO:0106435 ISS
Biological Process
    ethanol catabolic process GO:0006068 IEA
    acetaldehyde metabolic process GO:0006117 ISO
    intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISO
    response to organic cyclic compound GO:0014070 ISO
    nitroglycerin metabolic process GO:0018937 ISS
    negative regulation of apoptotic process GO:0043066 ISO
    aldehyde catabolic process GO:0046185 ISO
    aldehyde catabolic process GO:0046185 ISS
    behavioral response to ethanol GO:0048149 ISO
    cellular detoxification of aldehyde GO:0110095 ISO
    regulation of dopamine biosynthetic process GO:1903179 IMP
    regulation of serotonin biosynthetic process GO:1905627 IMP
    regulation of reactive oxygen species metabolic process GO:2000377 ISO
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrial matrix GO:0005759 IEA
    mitochondrial matrix GO:0005759 ISO
 Experiment description of studies that identified Aldh2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aldh2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mettl21e  
Affinity Capture-MS Mus musculus
2 Ufm1  
Co-fractionation Mus musculus
3 Mdh2 17448
Cross-Linking-MS (XL-MS) Mus musculus
4 Atp5a1 11946
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
5 Kctd13  
Affinity Capture-MS Mus musculus
6 Ufc1  
Co-fractionation Mus musculus
7 Hadha  
Cross-Linking-MS (XL-MS) Mus musculus
8 Atg16l1  
Affinity Capture-MS Mus musculus
9 Fancd2  
Affinity Capture-MS Mus musculus
10 Aldh2 11669
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here