Gene description for LRRC58
Gene name leucine rich repeat containing 58
Gene symbol LRRC58
Other names/aliases -
Species Homo sapiens
 Database cross references - LRRC58
ExoCarta ExoCarta_116064
Vesiclepedia VP_116064
Entrez Gene 116064
HGNC 26968
UniProt Q96CX6  
 LRRC58 identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for LRRC58
Biological Process
    intracellular signal transduction GO:0035556 IBA
 Experiment description of studies that identified LRRC58 in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for LRRC58
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UNK  
Affinity Capture-RNA Homo sapiens
2 XPO1 7514
Affinity Capture-MS Homo sapiens
3 CUL5 8065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SKP2  
Affinity Capture-MS Homo sapiens
5 TCEB2 6923
Affinity Capture-MS Homo sapiens
6 CDO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ATG14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 AR 367
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRC58 is involved
No pathways found





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