Gene description for Ace
Gene name	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Gene symbol	Ace
Other names/aliases	AW208573 CD143
Species	Mus musculus
Database cross references - Ace
ExoCarta	ExoCarta_11421
Vesiclepedia	VP_11421
Entrez Gene	11421
UniProt	P09470
Ace identified in sEVs derived from the following tissue/cell type
Faeces	33431899
Faeces	33431899

Gene ontology annotations for Ace

Molecular Function     actin binding GO:0003779 ISO     endopeptidase activity GO:0004175 ISO     carboxypeptidase activity GO:0004180 IEA     metallocarboxypeptidase activity GO:0004181 IDA     metalloendopeptidase activity GO:0004222 ISO     metalloendopeptidase activity GO:0004222 ISS     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 IEA     peptidase activity GO:0008233 IMP     peptidase activity GO:0008233 ISO     metallopeptidase activity GO:0008237 IBA     metallopeptidase activity GO:0008237 IDA     metallopeptidase activity GO:0008237 ISO     exopeptidase activity GO:0008238 ISO     tripeptidyl-peptidase activity GO:0008240 IEA     tripeptidyl-peptidase activity GO:0008240 ISO     peptidyl-dipeptidase activity GO:0008241 IBA     peptidyl-dipeptidase activity GO:0008241 IDA     peptidyl-dipeptidase activity GO:0008241 IMP     peptidyl-dipeptidase activity GO:0008241 ISO     zinc ion binding GO:0008270 IEA     zinc ion binding GO:0008270 ISO     chloride ion binding GO:0031404 ISO     chloride ion binding GO:0031404 ISS     mitogen-activated protein kinase kinase binding GO:0031434 IEA     mitogen-activated protein kinase kinase binding GO:0031434 ISO     bradykinin receptor binding GO:0031711 IEA     bradykinin receptor binding GO:0031711 ISO     mitogen-activated protein kinase binding GO:0051019 IEA     mitogen-activated protein kinase binding GO:0051019 ISO     metallodipeptidase activity GO:0070573 ISO     metallodipeptidase activity GO:0070573 ISS     heterocyclic compound binding GO:1901363 IEA     heterocyclic compound binding GO:1901363 ISO Biological Process     response to hypoxia GO:0001666 IEA     kidney development GO:0001822 IMP     kidney development GO:0001822 IMP     kidney development GO:0001822 ISO     angiotensin maturation GO:0002003 IDA     angiotensin maturation GO:0002003 IMP     angiotensin maturation GO:0002003 ISO     neutrophil mediated immunity GO:0002446 IMP     regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 IBA     regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 ISO     positive regulation of systemic arterial blood pressure GO:0003084 IBA     positive regulation of systemic arterial blood pressure GO:0003084 IMP     positive regulation of systemic arterial blood pressure GO:0003084 ISO     peptide metabolic process GO:0006518 ISO     spermatogenesis GO:0007283 IMP     female pregnancy GO:0007565 IEA     regulation of blood pressure GO:0008217 IDA     regulation of blood pressure GO:0008217 IMP     regulation of blood pressure GO:0008217 ISO     male gonad development GO:0008584 IMP     response to xenobiotic stimulus GO:0009410 IEA     embryo development ending in birth or egg hatching GO:0009792 IEA     embryo development ending in birth or egg hatching GO:0009792 ISO     post-transcriptional regulation of gene expression GO:0010608 IMP     negative regulation of gene expression GO:0010629 IMP     substance P catabolic process GO:0010814 ISO     substance P catabolic process GO:0010814 ISS     bradykinin catabolic process GO:0010815 ISO     bradykinin catabolic process GO:0010815 ISS     regulation of smooth muscle cell migration GO:0014910 IEA     regulation of smooth muscle cell migration GO:0014910 ISO     animal organ regeneration GO:0031100 IEA     animal organ regeneration GO:0031100 ISO     response to nutrient levels GO:0031667 IEA     response to lipopolysaccharide GO:0032496 IEA     response to lipopolysaccharide GO:0032496 ISO     response to laminar fluid shear stress GO:0034616 IEA     angiotensin-activated signaling pathway GO:0038166 IMP     vasoconstriction GO:0042310 IEA     vasoconstriction GO:0042310 ISO     hormone metabolic process GO:0042445 ISO     hormone catabolic process GO:0042447 IDA     hormone catabolic process GO:0042447 ISO     eating behavior GO:0042755 IEA     eating behavior GO:0042755 ISO     positive regulation of apoptotic process GO:0043065 IEA     positive regulation of apoptotic process GO:0043065 ISO     peptide catabolic process GO:0043171 ISO     positive regulation of blood pressure GO:0045777 ISO     positive regulation of vasoconstriction GO:0045907 IEA     positive regulation of vasoconstriction GO:0045907 ISO     negative regulation of D-glucose import GO:0046325 IEA     negative regulation of D-glucose import GO:0046325 ISO     regulation of synaptic plasticity GO:0048167 IDA     lung alveolus development GO:0048286 IEA     lung alveolus development GO:0048286 ISO     amyloid-beta metabolic process GO:0050435 IEA     amyloid-beta metabolic process GO:0050435 ISO     arachidonate secretion GO:0050482 IEA     arachidonate secretion GO:0050482 ISO     positive regulation of neurogenesis GO:0050769 IEA     positive regulation of neurogenesis GO:0050769 ISO     heart contraction GO:0060047 IMP     regulation of angiotensin metabolic process GO:0060177 IEA     regulation of angiotensin metabolic process GO:0060177 ISO     angiogenesis involved in coronary vascular morphogenesis GO:0060978 IEA     angiogenesis involved in coronary vascular morphogenesis GO:0060978 ISO     cellular response to glucose stimulus GO:0071333 IEA     response to dexamethasone GO:0071548 IEA     cell proliferation in bone marrow GO:0071838 IMP     regulation of heart rate by cardiac conduction GO:0086091 IMP     negative regulation of calcium ion import GO:0090281 IEA     negative regulation of calcium ion import GO:0090281 ISO     response to thyroid hormone GO:0097066 IEA     regulation of hematopoietic stem cell proliferation GO:1902033 IMP     negative regulation of gap junction assembly GO:1903597 IMP     cellular response to aldosterone GO:1904045 IEA     positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170 IMP Subcellular Localization     extracellular region GO:0005576 IDA     extracellular space GO:0005615 ISO     extracellular space GO:0005615 ISO     extracellular space GO:0005615 ISS     cytoplasm GO:0005737 IDA     lysosome GO:0005764 IEA     lysosome GO:0005764 ISO     endosome GO:0005768 IEA     endosome GO:0005768 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     external side of plasma membrane GO:0009897 IEA     external side of plasma membrane GO:0009897 ISO     basal plasma membrane GO:0009925 IEA     basal plasma membrane GO:0009925 ISO     brush border membrane GO:0031526 IEA     brush border membrane GO:0031526 ISO     vesicle GO:0031982 ISO     extracellular exosome GO:0070062 IEA     extracellular exosome GO:0070062 ISO     sperm midpiece GO:0097225 IEA     sperm midpiece GO:0097225 ISO