Gene description for CD300A
Gene name CD300a molecule
Gene symbol CD300A
Other names/aliases CLM-8
CMRF-35-H9
CMRF-35H
CMRF35-H
CMRF35-H9
CMRF35H
CMRF35H9
IGSF12
IRC1
IRC1/IRC2
IRC2
IRp60
Species Homo sapiens
 Database cross references - CD300A
ExoCarta ExoCarta_11314
Entrez Gene 11314
HGNC 19319
MIM 606790
UniProt Q9UGN4  
 CD300A identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for CD300A
Molecular Function
    phosphatidylserine binding GO:0001786 IDA
    phosphatidylethanolamine binding GO:0008429 IDA
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 IDA
Biological Process
    negative regulation of mast cell degranulation GO:0043305 IDA
    negative regulation of eosinophil activation GO:1902567 IDA
    signal transduction GO:0007165 IDA
    negative regulation of B cell receptor signaling pathway GO:0050859 IDA
    cell adhesion GO:0007155 IEA
    negative regulation of neutrophil activation GO:1902564 IDA
    negative regulation of fibroblast proliferation GO:0048147 IDA
    regulation of T cell receptor signaling pathway GO:0050856 IDA
    negative regulation of MAP kinase activity GO:0043407 IDA
    negative regulation of eosinophil migration GO:2000417 IDA
    negative regulation of phagocytosis, engulfment GO:0060101 IMP
    immune system process GO:0002376 IEA
    positive regulation of phosphoprotein phosphatase activity GO:0032516 IDA
    negative regulation of mast cell activation involved in immune response GO:0033007 IDA
    negative regulation of NK T cell activation GO:0051134 IDA
    negative regulation of activation of JAK2 kinase activity GO:1902569 IDA
    negative regulation of B cell proliferation GO:0030889 IMP
Subcellular Localization
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IDA
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified CD300A in exosomes
1
Experiment ID 79
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for CD300A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CD300A is involved
No pathways found





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