Gene description for Dek
Gene name DEK oncogene (DNA binding)
Gene symbol Dek
Other names/aliases 1810019E15Rik
D13H6S231E
Species Mus musculus
 Database cross references - Dek
ExoCarta ExoCarta_110052
Vesiclepedia VP_110052
Entrez Gene 110052
UniProt Q7TNV0  
 Dek identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dek
Molecular Function
    DNA binding GO:0003677 IEA
    histone binding GO:0042393 IBA
    histone binding GO:0042393 IEA
    histone binding GO:0042393 ISO
Biological Process
    chromatin remodeling GO:0006338 NAS
    cell quiescence GO:0044838 IMP
    positive regulation of transcription by RNA polymerase I GO:0045943 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    positive regulation of transcription by RNA polymerase III GO:0045945 ISO
    regulation of double-strand break repair GO:2000779 IBA
    regulation of double-strand break repair GO:2000779 ISO
    regulation of double-strand break repair via nonhomologous end joining GO:2001032 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 NAS
    contractile muscle fiber GO:0043292 IDA
    B-WICH complex GO:0110016 ISO
 Experiment description of studies that identified Dek in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dek
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Phf14  
Co-fractionation Mus musculus
3 Irf2bp2  
Co-fractionation Mus musculus
4 F13b  
Co-fractionation Mus musculus
5 Atxn1  
Affinity Capture-MS Mus musculus
6 Gpatch2  
Co-fractionation Mus musculus
7 H2afy 26914
Co-fractionation Mus musculus
8 Tlx3  
Two-hybrid Mus musculus
9 Ccnl1  
Co-fractionation Mus musculus
10 Twist1  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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