Gene description for Txndc5
Gene name thioredoxin domain containing 5
Gene symbol Txndc5
Other names/aliases AL022641
ERp46
PC-TRP
Species Mus musculus
 Database cross references - Txndc5
ExoCarta ExoCarta_105245
Entrez Gene 105245
UniProt Q91W90  
 Txndc5 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Txndc5
Molecular Function
    protein disulfide isomerase activity GO:0003756 IBA
    isomerase activity GO:0016853 IEA
Biological Process
    apoptotic cell clearance GO:0043277 IBA
    response to endoplasmic reticulum stress GO:0034976 IBA
    protein folding GO:0006457 IBA
    cell redox homeostasis GO:0045454 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum lumen GO:0005788 IDA
 Experiment description of studies that identified Txndc5 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Txndc5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Txndc5 is involved
PathwayEvidenceSource
Golgi Associated Vesicle Biogenesis IEA Reactome
Lysosome Vesicle Biogenesis IEA Reactome





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