Gene description for SUMO1
Gene name small ubiquitin-like modifier 1
Gene symbol SUMO1
Other names/aliases DAP1
GMP1
OFC10
PIC1
SENP2
SMT3
SMT3C
SMT3H3
UBL1
Species Homo sapiens
 Database cross references - SUMO1
ExoCarta ExoCarta_7341
Vesiclepedia VP_7341
Entrez Gene 7341
HGNC 12502
MIM 601912
UniProt P63165  
 SUMO1 identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Hepatocytes 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
 Gene ontology annotations for SUMO1
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 ISS
    potassium channel regulator activity GO:0015459 IDA
    enzyme binding GO:0019899 IPI
    protein tag activity GO:0031386 IBA
    protein tag activity GO:0031386 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    small protein activating enzyme binding GO:0044388 IPI
    ubiquitin-like protein ligase binding GO:0044389 IBA
    ubiquitin-specific protease binding GO:1990381 IPI
Biological Process
    DNA repair GO:0006281 TAS
    negative regulation of transcription by transcription factor localization GO:0010621 IDA
    protein sumoylation GO:0016925 IBA
    protein sumoylation GO:0016925 IDA
    protein sumoylation GO:0016925 IMP
    PML body organization GO:0030578 IEA
    positive regulation of protein-containing complex assembly GO:0031334 IDA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IDA
    regulation of protein localization GO:0032880 TAS
    cellular response to heat GO:0034605 IDA
    negative regulation of protein import into nucleus GO:0042308 IDA
    negative regulation of DNA binding GO:0043392 IDA
    negative regulation of DNA binding GO:0043392 IMP
    negative regulation of DNA-binding transcription factor activity GO:0043433 IMP
    negative regulation of action potential GO:0045759 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    protein stabilization GO:0050821 IDA
    roof of mouth development GO:0060021 ISS
    cellular response to cadmium ion GO:0071276 IDA
    regulation of cardiac muscle cell contraction GO:0086004 IEA
    protein localization to nuclear pore GO:0090204 IEA
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 IDA
    negative regulation of delayed rectifier potassium channel activity GO:1902260 IDA
    regulation of calcium ion transmembrane transport GO:1903169 IEA
Subcellular Localization
    XY body GO:0001741 IEA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nuclear pore GO:0005643 TAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    voltage-gated potassium channel complex GO:0008076 IDA
    nuclear body GO:0016604 IDA
    PML body GO:0016605 IBA
    PML body GO:0016605 IDA
    PML body GO:0016605 IDA
    nuclear speck GO:0016607 IEA
    nuclear membrane GO:0031965 IDA
    nuclear stress granule GO:0097165 IDA
    glutamatergic synapse GO:0098978 IEA
    presynaptic cytosol GO:0099523 IEA
    postsynaptic cytosol GO:0099524 IEA
 Experiment description of studies that identified SUMO1 in sEVs
1
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
2
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
12
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
13
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
14
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
17
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for SUMO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Grm8  
Affinity Capture-Western Rattus norvegicus
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 RBMXL1  
Affinity Capture-MS Homo sapiens
4 HNRNPC 3183
Two-hybrid Homo sapiens
5 PRDX5 25824
Co-fractionation Homo sapiens
6 HDAC4  
Affinity Capture-MS Homo sapiens
7 CBX1 10951
Affinity Capture-MS Homo sapiens
8 ETV6  
Two-hybrid Homo sapiens
9 USPL1  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
10 TRAF4 9618
Two-hybrid Homo sapiens
11 Rcc1  
Affinity Capture-MS Mus musculus
12 PKM 5315
Reconstituted Complex Homo sapiens
13 TOP2B 7155
Two-hybrid Homo sapiens
14 UTP11L  
Affinity Capture-MS Homo sapiens
15 ARPC4 10093
Co-fractionation Homo sapiens
16 PRPF38A 84950
Affinity Capture-MS Homo sapiens
17 KPNB1 3837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 GLP1R  
Affinity Capture-Western Homo sapiens
19 BRCA1 672
FRET Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
20 C9orf78 51759
Affinity Capture-MS Homo sapiens
21 SETX  
Two-hybrid Homo sapiens
22 UBC 7316
Affinity Capture-Western Homo sapiens
23 PAK2 5062
Affinity Capture-MS Homo sapiens
24 SCAF4 57466
Affinity Capture-MS Homo sapiens
25 RHOXF2  
Two-hybrid Homo sapiens
26 PARK7 11315
Two-hybrid Homo sapiens
27 ISG15 9636
Reconstituted Complex Homo sapiens
28 SOX2  
Two-hybrid Homo sapiens
29 Dnm1 140694
Reconstituted Complex Rattus norvegicus
30 RPS3 6188
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
31 MAP3K5 4217
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 NR1H4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 SAE1 10055
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
34 GTF2F2 2963
Affinity Capture-MS Homo sapiens
35 CHAF1A  
Reconstituted Complex Homo sapiens
36 PRPF38B 55119
Affinity Capture-MS Homo sapiens
37 C18orf25 147339
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 SENP1  
Co-crystal Structure Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
39 NUP153 9972
Affinity Capture-MS Homo sapiens
40 CWC25 54883
Affinity Capture-MS Homo sapiens
41 HGS 9146
Two-hybrid Homo sapiens
42 TDP2 51567
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
43 RWDD3  
Affinity Capture-Western Homo sapiens
44 ZFP42  
Two-hybrid Homo sapiens
45 OBSL1 23363
Affinity Capture-MS Homo sapiens
46 ZNF451 26036
Reconstituted Complex Homo sapiens
47 RAD51  
Two-hybrid Homo sapiens
48 ZGPAT  
Affinity Capture-MS Homo sapiens
49 TP63  
Affinity Capture-Western Homo sapiens
50 CCDC67  
Two-hybrid Homo sapiens
51 RCC1 1104
Affinity Capture-MS Homo sapiens
52 BRD4 23476
Affinity Capture-MS Homo sapiens
53 BIRC3 330
Two-hybrid Homo sapiens
54 BLM 641
Two-hybrid Homo sapiens
55 CACTIN  
Affinity Capture-MS Homo sapiens
56 ARPC1B 10095
Co-fractionation Homo sapiens
57 DNM1 1759
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
58 TFCP2 7024
Two-hybrid Homo sapiens
59 CHD3 1107
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
60 CARD9 64170
Two-hybrid Homo sapiens
61 TDG 6996
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
62 UIMC1  
Affinity Capture-Western Homo sapiens
63 KIF14 9928
Affinity Capture-MS Homo sapiens
64 FAS 355
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
65 WRN 7486
Two-hybrid Homo sapiens
66 CCR2  
Two-hybrid Homo sapiens
67 ZHX1  
Two-hybrid Homo sapiens
68 ZMYM3  
Reconstituted Complex Homo sapiens
69 SENP2 59343
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
70 MYB  
Reconstituted Complex Homo sapiens
71 RNF4 6047
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
72 Mafb  
Affinity Capture-Western Mus musculus
73 PARK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
74 ZBTB16  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
75 PIAS4  
Two-hybrid Homo sapiens
76 NCOR2  
Biochemical Activity Homo sapiens
77 SIMC1  
Affinity Capture-Western Homo sapiens
78 MAD1L1  
Co-localization Homo sapiens
79 MAPRE1 22919
Affinity Capture-MS Homo sapiens
80 PDZD11 51248
Affinity Capture-MS Homo sapiens
81 C11orf65  
Two-hybrid Homo sapiens
82 ATF2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
83 KPNA4 3840
Affinity Capture-MS Homo sapiens
84 UBE2I 7329
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
85 PFDN2 5202
Co-fractionation Homo sapiens
86 PABPC1 26986
Co-fractionation Homo sapiens
87 FAM118B  
Two-hybrid Homo sapiens
88 YAP1 10413
Affinity Capture-Western Homo sapiens
89 VCP 7415
Affinity Capture-MS Homo sapiens
90 SLX4  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
91 BTBD3  
Two-hybrid Homo sapiens
92 PIAS2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
93 Hipk2  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
94 DTX2 113878
Two-hybrid Homo sapiens
95 RRP36 88745
Affinity Capture-MS Homo sapiens
96 RPA4  
Proximity Label-MS Homo sapiens
97 UBTF 7343
Affinity Capture-MS Homo sapiens
98 PML 5371
Two-hybrid Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
99 SNRNP27  
Affinity Capture-MS Homo sapiens
100 BGLF4  
Reconstituted Complex
101 RAB11FIP5 26056
Co-fractionation Homo sapiens
102 SUMO1 7341
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
103 Ube2i  
Two-hybrid Mus musculus
Co-crystal Structure Mus musculus
Affinity Capture-MS Mus musculus
104 PSMD2 5708
Co-fractionation Homo sapiens
105 CEBPA  
Protein-peptide Homo sapiens
106 PRKACB 5567
Co-fractionation Homo sapiens
107 DAXX  
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
108 Nup155  
Affinity Capture-MS Mus musculus
109 ZBED1  
Reconstituted Complex Homo sapiens
110 SP100 6672
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
111 RAN 5901
Affinity Capture-MS Homo sapiens
112 WDR46  
Affinity Capture-MS Homo sapiens
113 ATXN1 6310
Two-hybrid Homo sapiens
114 PHLPP1  
Proximity Label-MS Homo sapiens
115 CBX4  
Affinity Capture-MS Homo sapiens
116 NUMA1 4926
Affinity Capture-MS Homo sapiens
117 TJP1 7082
Affinity Capture-MS Homo sapiens
118 PAX6  
Reconstituted Complex Homo sapiens
119 ZBTB2 57621
Two-hybrid Homo sapiens
120 MITF  
Affinity Capture-Western Homo sapiens
121 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
122 FANCD2  
Affinity Capture-MS Homo sapiens
123 CUL3 8452
Affinity Capture-MS Homo sapiens
124 Nup98  
Affinity Capture-MS Mus musculus
125 TMIE  
Two-hybrid Homo sapiens
126 XPO1 7514
Affinity Capture-MS Homo sapiens
127 IKZF3  
Two-hybrid Homo sapiens
128 Slc1a2  
Two-hybrid Mus musculus
129 RAD52  
Two-hybrid Homo sapiens
130 TNFRSF1A 7132
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
131 MX1 4599
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
132 NR3C1 2908
Affinity Capture-Western Homo sapiens
133 MECP2 4204
Affinity Capture-MS Homo sapiens
134 PIAS3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
135 RBM27  
Affinity Capture-MS Homo sapiens
136 TP73  
Two-hybrid Homo sapiens
137 ZCCHC12  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
138 ZCCHC7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
139 RP9  
Affinity Capture-MS Homo sapiens
140 JUN 3725
PCA Homo sapiens
141 PPIL3 53938
Co-fractionation Homo sapiens
142 DNMT3B  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
143 UBA2 10054
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
144 TJP2 9414
Affinity Capture-MS Homo sapiens
145 PIAS1 8554
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
146 Nup107  
Affinity Capture-MS Mus musculus
147 NUTF2 10204
Affinity Capture-MS Homo sapiens
148 RAD54B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
149 MTOR 2475
Biochemical Activity Homo sapiens
150 PHC1  
Two-hybrid Homo sapiens
151 GOLGA1  
Proximity Label-MS Homo sapiens
152 ZBTB6  
Two-hybrid Homo sapiens
153 ARC  
Affinity Capture-Western Homo sapiens
154 KAT5  
Affinity Capture-MS Homo sapiens
155 TRAF2 7186
Two-hybrid Homo sapiens
156 RANBP1 5902
Affinity Capture-MS Homo sapiens
157 EDARADD  
Two-hybrid Homo sapiens
158 SEH1L 81929
Affinity Capture-MS Homo sapiens
159 SUMO1P1  
Two-hybrid Homo sapiens
160 FBF1  
Two-hybrid Homo sapiens
161 GMCL1  
Two-hybrid Homo sapiens
162 TSC22D3  
Reconstituted Complex Homo sapiens
163 PROP1  
Two-hybrid Homo sapiens
164 BRD3 8019
Affinity Capture-MS Homo sapiens
165 ZMYM2  
Two-hybrid Homo sapiens
166 MDM2  
Biochemical Activity Homo sapiens
167 Plk1  
Affinity Capture-MS Mus musculus
168 PTGS2 5743
Affinity Capture-Western Homo sapiens
169 SATB1 6304
Two-hybrid Homo sapiens
170 MAPK1IP1L 93487
Two-hybrid Homo sapiens
171 DDX46 9879
Affinity Capture-MS Homo sapiens
172 MIB1 57534
Proximity Label-MS Homo sapiens
173 TRIM5 85363
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
174 ARRB2 409
Reconstituted Complex Homo sapiens
175 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
176 MUL1  
Biochemical Activity Homo sapiens
177 SPOP  
Two-hybrid Homo sapiens
178 PRRC2A 7916
Affinity Capture-MS Homo sapiens
179 TOE1 114034
Two-hybrid Homo sapiens
180 PARP1 142
Affinity Capture-MS Homo sapiens
181 BKRF1  
Affinity Capture-Western
Reconstituted Complex
182 CASP2  
Two-hybrid Homo sapiens
183 TRPS1  
Two-hybrid Homo sapiens
184 USP25  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
185 TP53 7157
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
186 Daxx  
Co-crystal Structure Mus musculus
187 SENP6  
Biochemical Activity Homo sapiens
188 RAD54L2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
189 SULT1A1 6817
Co-fractionation Homo sapiens
190 ATXN7  
Reconstituted Complex Homo sapiens
191 BUB1B  
Affinity Capture-Western Homo sapiens
192 HIPK3 10114
Two-hybrid Homo sapiens
193 ZMYM5 9205
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
194 ARPC2 10109
Co-fractionation Homo sapiens
195 ZBTB26  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
196 NR3C2  
Two-hybrid Homo sapiens
197 BID  
Co-fractionation Homo sapiens
198 SMAD4  
Affinity Capture-Western Homo sapiens
199 CREBBP  
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
200 LSS 4047
Affinity Capture-MS Homo sapiens
201 SALL1 6299
Two-hybrid Homo sapiens
202 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
203 MKI67  
Affinity Capture-MS Homo sapiens
204 HNRNPK 3190
Reconstituted Complex Homo sapiens
205 Stat92E  
Affinity Capture-Western Drosophila melanogaster
206 PCNA 5111
Reconstituted Complex Homo sapiens
207 KLF5  
Affinity Capture-Western Homo sapiens
208 MIF 4282
Affinity Capture-MS Homo sapiens
209 NUP107 57122
Affinity Capture-MS Homo sapiens
210 SNIP1  
Affinity Capture-MS Homo sapiens
211 DHX16 8449
Affinity Capture-MS Homo sapiens
212 Senp1  
Reconstituted Complex Mus musculus
Biochemical Activity Mus musculus
213 GLI2  
Proximity Label-MS Homo sapiens
214 SSSCA1 10534
Co-fractionation Homo sapiens
215 RNF111 54778
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
216 Ranbp2  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
217 FOXM1  
FRET Homo sapiens
218 TOPORS  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
219 HIPK2 28996
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
220 CUL7 9820
Affinity Capture-MS Homo sapiens
221 CASP8AP2  
Affinity Capture-Western Homo sapiens
222 ATXN3 4287
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
223 CDK6 1021
Biochemical Activity Homo sapiens
224 SSRP1 6749
Affinity Capture-MS Homo sapiens
225 RANGAP1 5905
Reconstituted Complex Homo sapiens
226 RANBP2 5903
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
227 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SUMO1 is involved
PathwayEvidenceSource
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Disease IEA Reactome
Disease TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
Formation of Incision Complex in GG-NER TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway IEA Reactome
Generic Transcription Pathway TAS Reactome
Global Genome Nucleotide Excision Repair (GG-NER) TAS Reactome
Immune System TAS Reactome
Infectious disease IEA Reactome
Infectious disease TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome
Late SARS-CoV-2 Infection Events IEA Reactome
M Phase TAS Reactome
Maturation of nucleoprotein TAS Reactome
Maturation of nucleoprotein IEA Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Mitotic Anaphase TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors IEA Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors TAS Reactome
Nuclear Envelope (NE) Reassembly TAS Reactome
Nucleotide Excision Repair TAS Reactome
PKR-mediated signaling TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
Postmitotic nuclear pore complex (NPC) reformation TAS Reactome
Processing and activation of SUMO TAS Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of IFNG signaling TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RNA Polymerase II Transcription TAS Reactome
SARS-CoV Infections IEA Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-2 Infection IEA Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMO is conjugated to E1 (UBA2:SAE1) TAS Reactome
SUMO is proteolytically processed TAS Reactome
SUMO is transferred from E1 to E2 (UBE2I, UBC9) TAS Reactome
SUMOylation TAS Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins TAS Reactome
SUMOylation of chromatin organization proteins IEA Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome
SUMOylation of DNA methylation proteins TAS Reactome
SUMOylation of DNA methylation proteins IEA Reactome
SUMOylation of DNA replication proteins TAS Reactome
SUMOylation of DNA replication proteins IEA Reactome
SUMOylation of immune response proteins TAS Reactome
SUMOylation of intracellular receptors TAS Reactome
SUMOylation of intracellular receptors IEA Reactome
SUMOylation of nuclear envelope proteins TAS Reactome
SUMOylation of RNA binding proteins TAS Reactome
SUMOylation of SUMOylation proteins TAS Reactome
SUMOylation of transcription cofactors TAS Reactome
SUMOylation of transcription cofactors IEA Reactome
SUMOylation of transcription factors IEA Reactome
SUMOylation of transcription factors TAS Reactome
SUMOylation of ubiquitinylation proteins TAS Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors IEA Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TAS Reactome
Translation of Structural Proteins TAS Reactome
Translation of Structural Proteins IEA Reactome
Viral Infection Pathways IEA Reactome
Viral Infection Pathways TAS Reactome





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