Gene description for Tceb2
Gene name transcription elongation factor B (SIII), polypeptide 2
Gene symbol Tceb2
Other names/aliases 0610040H15Rik
Species Mus musculus
 Database cross references - Tceb2
ExoCarta ExoCarta_67673
Vesiclepedia VP_67673
Entrez Gene 67673
UniProt P62869  
 Tceb2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tceb2
Molecular Function
    transcription corepressor binding GO:0001222 IEA
    transcription corepressor binding GO:0001222 ISO
    transcription coactivator activity GO:0003713 ISO
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    protein-containing complex binding GO:0044877 ISO
Biological Process
    transcription initiation at RNA polymerase II promoter GO:0006367 IEA
    transcription initiation at RNA polymerase II promoter GO:0006367 ISO
    transcription elongation by RNA polymerase II GO:0006368 IEA
    protein ubiquitination GO:0016567 IEA
    target-directed miRNA degradation GO:0140958 IEA
    target-directed miRNA degradation GO:0140958 ISO
Subcellular Localization
    transcription regulator complex GO:0005667 ISO
    cytosol GO:0005829 TAS
    VCB complex GO:0030891 IBA
    VCB complex GO:0030891 IEA
    VCB complex GO:0030891 ISO
    Cul2-RING ubiquitin ligase complex GO:0031462 IEA
    Cul2-RING ubiquitin ligase complex GO:0031462 ISO
    Cul5-RING ubiquitin ligase complex GO:0031466 IDA
    Cul5-RING ubiquitin ligase complex GO:0031466 ISO
    elongin complex GO:0070449 IBA
    elongin complex GO:0070449 IDA
    elongin complex GO:0070449 ISO
 Experiment description of studies that identified Tceb2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tceb2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rbx1  
Co-fractionation Mus musculus
2 Rnf7  
Co-fractionation Mus musculus
3 Nrbp1 192292
Affinity Capture-Western Mus musculus
4 Hoxa10  
Two-hybrid Mus musculus
5 Tceb1  
Co-crystal Structure Mus musculus
6 SOCS3 9021
Affinity Capture-Western Homo sapiens
7 Fancd2  
Affinity Capture-MS Mus musculus
8 Zer1  
Co-fractionation Mus musculus
9 Wsb1  
Reconstituted Complex Mus musculus
10 Socs3  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
11 Atg16l1  
Affinity Capture-MS Mus musculus
12 VHL  
Affinity Capture-Western Homo sapiens
13 Asb2  
Reconstituted Complex Mus musculus
14 gus  
Co-crystal Structure Drosophila melanogaster
15 Socs2  
Affinity Capture-MS Mus musculus
16 Socs1  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
17 Rara  
Reconstituted Complex Mus musculus
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