Gene description for Nrbp1
Gene name nuclear receptor binding protein 1
Gene symbol Nrbp1
Other names/aliases B230344L17Rik
Nrbp
Species Mus musculus
 Database cross references - Nrbp1
ExoCarta ExoCarta_192292
Vesiclepedia VP_192292
Entrez Gene 192292
UniProt Q99J45  
 Nrbp1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Nrbp1
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 ISO
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    in utero embryonic development GO:0001701 IMP
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 ISO
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 ISS
    JNK cascade GO:0007254 ISO
    epithelial cell differentiation GO:0030855 IMP
    intracellular signal transduction GO:0035556 IBA
    epithelial cell proliferation GO:0050673 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cell cortex GO:0005938 IEA
    endomembrane system GO:0012505 IBA
    endomembrane system GO:0012505 ISO
    membrane GO:0016020 IEA
    lamellipodium GO:0030027 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified Nrbp1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Nrbp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ribc2  
Co-fractionation Mus musculus
2 Mlf1  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
3 Tceb1  
Affinity Capture-Western Mus musculus
4 Sall4  
Affinity Capture-Western Mus musculus
5 Rif1  
Co-fractionation Mus musculus
6 Cul5 75717
Affinity Capture-Western Mus musculus
7 Tceb2 67673
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Nrbp1 is involved
No pathways found





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