Gene description for Vta1
Gene name Vps20-associated 1 homolog (S. cerevisiae)
Gene symbol Vta1
Other names/aliases 1110001D18Rik
1110059P08Rik
AU040813
C85340
LIP5
SBP1
Species Mus musculus
 Database cross references - Vta1
ExoCarta ExoCarta_66201
Vesiclepedia VP_66201
Entrez Gene 66201
UniProt Q9CR26  
 Vta1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Vta1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein transport GO:0015031 IEA
    late endosome to vacuole transport via multivesicular body sorting pathway GO:0032511 IBA
    late endosome to vacuole transport via multivesicular body sorting pathway GO:0032511 IEA
    multivesicular body sorting pathway GO:0071985 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IDA
    multivesicular body GO:0005771 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    endosome membrane GO:0010008 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Vta1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Vta1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Vps4b 20479
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
Co-fractionation Mus musculus
2 GSK3A 2931
Two-hybrid Homo sapiens
3 Chmp1a  
Co-fractionation Mus musculus
4 Gsk3a  
Co-fractionation Mus musculus
5 GSK3B 2932
Two-hybrid Homo sapiens
6 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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