Gene description for MYBL2
Gene name v-myb avian myeloblastosis viral oncogene homolog-like 2
Gene symbol MYBL2
Other names/aliases B-MYB
BMYB
Species Homo sapiens
 Database cross references - MYBL2
ExoCarta ExoCarta_4605
Vesiclepedia VP_4605
Entrez Gene 4605
HGNC 7548
MIM 601415
UniProt P10244  
 MYBL2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MYBL2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    mitotic cell cycle GO:0000278 IBA
    positive regulation of neuron apoptotic process GO:0043525 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    mitotic spindle assembly GO:0090307 IEA
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    Myb complex GO:0031523 IEA
 Experiment description of studies that identified MYBL2 in sEVs
1
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MYBL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 NUF2  
Affinity Capture-MS Homo sapiens
3 GATAD2B 57459
Affinity Capture-MS Homo sapiens
4 HDAC2 3066
Affinity Capture-MS Homo sapiens
5 COIL  
Proximity Label-MS Homo sapiens
6 FEV  
Proximity Label-MS Homo sapiens
7 ZNF296  
Affinity Capture-MS Homo sapiens
8 E2F1 1869
Two-hybrid Homo sapiens
9 SAP30 8819
Affinity Capture-MS Homo sapiens
10 SOX2  
Proximity Label-MS Homo sapiens
11 MAP1LC3B 81631
Two-hybrid Homo sapiens
12 CAPZB 832
Affinity Capture-MS Homo sapiens
13 MTF2  
Affinity Capture-MS Homo sapiens
14 CHAF1A  
Affinity Capture-MS Homo sapiens
15 KLF8  
Proximity Label-MS Homo sapiens
16 CTDSPL2  
Affinity Capture-MS Homo sapiens
17 SMARCA1 6594
Affinity Capture-MS Homo sapiens
18 CDK2AP1  
Affinity Capture-MS Homo sapiens
19 ARID4B  
Affinity Capture-MS Homo sapiens
20 ELF4 2000
Proximity Label-MS Homo sapiens
21 KLF15  
Proximity Label-MS Homo sapiens
22 DDOST 1650
Affinity Capture-MS Homo sapiens
23 ZNF512B  
Affinity Capture-MS Homo sapiens
24 CDKN1C  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
25 EED  
Affinity Capture-MS Homo sapiens
26 TEAD2  
Affinity Capture-MS Homo sapiens
27 ZNF219  
Affinity Capture-MS Homo sapiens
28 PHF1  
Affinity Capture-MS Homo sapiens
29 ASF1A 25842
Proximity Label-MS Homo sapiens
30 MTA2 9219
Affinity Capture-MS Homo sapiens
31 TRIM15  
Two-hybrid Homo sapiens
32 KLF16  
Proximity Label-MS Homo sapiens
33 SHPRH  
Affinity Capture-MS Homo sapiens
34 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
35 CDC20 991
Affinity Capture-Western Homo sapiens
36 UBE2D4  
Two-hybrid Homo sapiens
37 CCNF  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
38 C17orf49 124944
Affinity Capture-MS Homo sapiens
39 NFIX 4784
Proximity Label-MS Homo sapiens
40 CBX3 11335
Proximity Label-MS Homo sapiens
41 LIN52  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 LHX3  
Proximity Label-MS Homo sapiens
43 BPTF 2186
Affinity Capture-MS Homo sapiens
44 ZSCAN26  
Affinity Capture-MS Homo sapiens
45 PNMA2  
Affinity Capture-MS Homo sapiens
46 SUZ12  
Affinity Capture-MS Homo sapiens
47 MYBL2 4605
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
48 MBD2 8932
Affinity Capture-MS Homo sapiens
49 RPN1 6184
Affinity Capture-MS Homo sapiens
50 CHD5 26038
Affinity Capture-MS Homo sapiens
51 LZTR1 8216
Two-hybrid Homo sapiens
52 MRPL22  
Affinity Capture-MS Homo sapiens
53 PHF12  
Affinity Capture-MS Homo sapiens
54 CEBPA  
Proximity Label-MS Homo sapiens
55 NLK  
Affinity Capture-Western Homo sapiens
56 CCNT1  
Phenotypic Suppression Homo sapiens
57 RBL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
58 BCL11A 53335
Affinity Capture-MS Homo sapiens
59 PAX6  
Proximity Label-MS Homo sapiens
60 CXCR4 7852
Two-hybrid Homo sapiens
61 RPN2 6185
Affinity Capture-MS Homo sapiens
62 Pank4  
Affinity Capture-MS Mus musculus
63 PLA2G4A 5321
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 SMARCA5 8467
Affinity Capture-MS Homo sapiens
65 ZNF622 90441
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
66 SKP2  
Affinity Capture-Western Homo sapiens
67 NR3C1 2908
Proximity Label-MS Homo sapiens
68 TTF2 8458
Two-hybrid Homo sapiens
69 BRMS1L  
Affinity Capture-MS Homo sapiens
70 HNF4A  
Proximity Label-MS Homo sapiens
71 CDK2 1017
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
72 MAPK6  
Two-hybrid Homo sapiens
73 LIN9  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
74 MYC  
Proximity Label-MS Homo sapiens
75 HJURP  
Affinity Capture-MS Homo sapiens
76 IRF8  
Proximity Label-MS Homo sapiens
77 CHD3 1107
Affinity Capture-MS Homo sapiens
78 ELF2  
Proximity Label-MS Homo sapiens
79 CCNA1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
80 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
81 HAT1 8520
Affinity Capture-MS Homo sapiens
82 SIN3B  
Affinity Capture-MS Homo sapiens
83 OST4  
Affinity Capture-MS Homo sapiens
84 GATAD2A 54815
Affinity Capture-MS Homo sapiens
85 BCL11B  
Affinity Capture-MS Homo sapiens
86 SUDS3  
Affinity Capture-MS Homo sapiens
87 PARP1 142
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
88 SAP130  
Affinity Capture-MS Homo sapiens
89 SIN3A  
Affinity Capture-MS Homo sapiens
90 MBD3 53615
Affinity Capture-MS Homo sapiens
91 MTA1 9112
Affinity Capture-MS Homo sapiens
92 DPY30 84661
Affinity Capture-MS Homo sapiens
93 Lin54  
Affinity Capture-MS Mus musculus
94 CREBBP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
95 CHD4 1108
Affinity Capture-MS Homo sapiens
96 EZH1  
Affinity Capture-MS Homo sapiens
97 HMGXB4 10042
Affinity Capture-MS Homo sapiens
98 E2F3  
Two-hybrid Homo sapiens
99 PPP2R3C  
Affinity Capture-MS Homo sapiens
100 EZH2  
Affinity Capture-MS Homo sapiens
101 ZBTB9  
Two-hybrid Homo sapiens
102 CDK9 1025
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
103 LIN54  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
104 FOXM1  
Affinity Capture-MS Homo sapiens
105 MTA3 57504
Affinity Capture-MS Homo sapiens
106 HIPK2 28996
Affinity Capture-Western Homo sapiens
107 STT3B 201595
Affinity Capture-MS Homo sapiens
108 KRAS 3845
Negative Genetic Homo sapiens
109 GATAD1  
Affinity Capture-MS Homo sapiens
110 CHAF1B  
Affinity Capture-MS Homo sapiens
111 PWWP2A  
Affinity Capture-MS Homo sapiens
112 RBBP4 5928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
113 FBXO38 81545
Proximity Label-MS Homo sapiens
114 SP7  
Proximity Label-MS Homo sapiens
115 LIN37  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
116 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
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