Gene description for Krt17
Gene name keratin 17
Gene symbol Krt17
Other names/aliases K17
Krt1-17
Species Mus musculus
 Database cross references - Krt17
ExoCarta ExoCarta_16667
Vesiclepedia VP_16667
Entrez Gene 16667
UniProt Q9QWL7  
 Krt17 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt17
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
Biological Process
    morphogenesis of an epithelium GO:0002009 IGI
    positive regulation of cell growth GO:0030307 IMP
    epithelial cell differentiation GO:0030855 IBA
    hair follicle morphogenesis GO:0031069 IMP
    keratinization GO:0031424 IGI
    intermediate filament organization GO:0045109 IBA
    intermediate filament organization GO:0045109 IGI
    positive regulation of translation GO:0045727 IMP
    positive regulation of hair follicle development GO:0051798 IMP
Subcellular Localization
    cornified envelope GO:0001533 IDA
    cytoplasm GO:0005737 IDA
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 IEA
    intermediate filament cytoskeleton GO:0045111 ISO
    cell periphery GO:0071944 IDA
 Experiment description of studies that identified Krt17 in sEVs
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Inppl1  
Co-fractionation Mus musculus
2 Nphp4  
Affinity Capture-MS Mus musculus
3 Atxn1  
Affinity Capture-MS Mus musculus
4 Pik3r2  
Co-fractionation Mus musculus
5 Usp7  
Affinity Capture-MS Mus musculus
6 Ubash3b  
Co-fractionation Mus musculus
7 Trim69  
Co-fractionation Mus musculus
8 Mks1  
Affinity Capture-MS Mus musculus
9 Iqcb1  
Affinity Capture-MS Mus musculus
10 Tut1  
Co-fractionation Mus musculus
11 Krt5 110308
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Krt17 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the cornified envelope IEA Reactome
Keratinization IEA Reactome





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