Gene description for B2m
Gene name	beta-2 microglobulin
Gene symbol	B2m
Other names/aliases	Ly-m11 beta2-m beta2m
Species	Mus musculus
Database cross references - B2m
ExoCarta	ExoCarta_12010
Vesiclepedia	VP_12010
Entrez Gene	12010
UniProt	P01887
B2m identified in sEVs derived from the following tissue/cell type
Neural stem cells	25242146
Neural stem cells	25242146

Gene ontology annotations for B2m

Molecular Function     structural molecule activity GO:0005198 IEA     structural molecule activity GO:0005198 ISO     protein binding GO:0005515 IPI     MHC class II protein complex binding GO:0023026 IBA     peptide antigen binding GO:0042605 IBA     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO Biological Process     T cell mediated cytotoxicity GO:0001913 IMP     positive regulation of T cell mediated cytotoxicity GO:0001916 IMP     response to molecule of bacterial origin GO:0002237 IMP     antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 IMP     peptide antigen assembly with MHC class I protein complex GO:0002502 IEA     peptide antigen assembly with MHC class I protein complex GO:0002502 ISO     peptide antigen assembly with MHC class II protein complex GO:0002503 IBA     positive regulation of T cell cytokine production GO:0002726 IEA     positive regulation of T cell cytokine production GO:0002726 ISO     regulation of membrane depolarization GO:0003254 ISO     iron ion transport GO:0006826 IMP     intracellular iron ion homeostasis GO:0006879 IEA     intracellular iron ion homeostasis GO:0006879 ISO     cellular defense response GO:0006968 TAS     sensory perception of smell GO:0007608 IMP     learning or memory GO:0007611 IMP     learning or memory GO:0007611 ISO     negative regulation of neuron projection development GO:0010977 IGI     antibacterial humoral response GO:0019731 ISO     antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IEA     antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 ISO     antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IBA     positive regulation of protein binding GO:0032092 ISO     T cell differentiation in thymus GO:0033077 IGI     regulation of iron ion transport GO:0034756 IEA     regulation of iron ion transport GO:0034756 ISO     protein refolding GO:0042026 IDA     innate immune response GO:0045087 ISO     regulation of erythrocyte differentiation GO:0045646 IMP     positive regulation of receptor-mediated endocytosis GO:0048260 IEA     positive regulation of receptor-mediated endocytosis GO:0048260 ISO     negative regulation of epithelial cell proliferation GO:0050680 IEA     negative regulation of epithelial cell proliferation GO:0050680 ISO     negative regulation of neurogenesis GO:0050768 IMP     negative regulation of neurogenesis GO:0050768 ISO     positive regulation of immune response GO:0050778 IBA     defense response to Gram-negative bacterium GO:0050829 ISO     defense response to Gram-positive bacterium GO:0050830 ISO     positive regulation of T cell activation GO:0050870 IBA     protein homotetramerization GO:0051289 IEA     protein homotetramerization GO:0051289 ISO     multicellular organismal-level iron ion homeostasis GO:0060586 IMP     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO     cellular response to lipopolysaccharide GO:0071222 ISO     cellular response to iron ion GO:0071281 ISO     cellular response to iron(III) ion GO:0071283 IMP     cellular response to nicotine GO:0071316 IEA     cellular response to nicotine GO:0071316 ISO     negative regulation of receptor binding GO:1900121 ISO     positive regulation of receptor binding GO:1900122 ISO     positive regulation of ferrous iron binding GO:1904434 ISO     positive regulation of transferrin receptor binding GO:1904437 ISO     amyloid fibril formation GO:1990000 IEA     amyloid fibril formation GO:1990000 ISO     positive regulation of cellular senescence GO:2000774 IEA     positive regulation of cellular senescence GO:2000774 ISO     negative regulation of forebrain neuron differentiation GO:2000978 IMP     negative regulation of forebrain neuron differentiation GO:2000978 ISO Subcellular Localization     extracellular space GO:0005615 HDA     extracellular space GO:0005615 ISO     lysosomal membrane GO:0005765 IBA     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 ISO     external side of plasma membrane GO:0009897 IDA     phagocytic vesicle membrane GO:0030670 TAS     late endosome membrane GO:0031902 IBA     MHC class I protein complex GO:0042612 IEA     MHC class II protein complex GO:0042613 IBA     MHC class I peptide loading complex GO:0042824 IEA     MHC class I peptide loading complex GO:0042824 ISO     HFE-transferrin receptor complex GO:1990712 IEA     HFE-transferrin receptor complex GO:1990712 ISO