Experiment description of studies that identified LARP4 in sEVs

1 Experiment ID 497 MISEV standards ✘ Biophysical techniques ✔ Enriched markers ✘ Negative markers ✔ Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35931686     Organism Homo sapiens Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD." Journal name Cell Death Dis Publication year 2022 Sample Chondrocytes Sample name T/C-28a2 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

2 Experiment ID 498 MISEV standards ✔ Biophysical techniques ✔ Enriched markers ✘ Negative markers ✔ Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35931686     Organism Homo sapiens Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD." Journal name Cell Death Dis Publication year 2022 Sample Chondrocytes Sample name T/C-28a2 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

Protein-protein interactions for LARP4

Protein Interactor ExoCarta ID Identification method PubMed Species 1 HNRNPH1 3187 Affinity Capture-RNA Homo sapiens 2 CCL3   Affinity Capture-MS Homo sapiens 3 RPSA 3921 Co-fractionation Homo sapiens 4 EXOSC7 23016 Two-hybrid Homo sapiens 5 ZC3H7A   Two-hybrid Homo sapiens 6 MTCH1 23787 Proximity Label-MS Homo sapiens 7 APOBEC3D   Affinity Capture-MS Homo sapiens 8 ZNF346   Affinity Capture-MS Homo sapiens 9 PDAP1 11333 Cross-Linking-MS (XL-MS) Homo sapiens 10 TARDBP 23435 Affinity Capture-MS Homo sapiens 11 COPS6 10980 Affinity Capture-MS Homo sapiens 12 RPS19 6223 Co-fractionation Homo sapiens 13 RPL10 6134 Affinity Capture-MS Homo sapiens 14 BPNT1 10380 Affinity Capture-MS Homo sapiens 15 PTPN1 5770 Proximity Label-MS Homo sapiens 16 APP 351 Reconstituted Complex Homo sapiens 17 RPS3 6188 Co-fractionation Homo sapiens 18 APEX1 328 Affinity Capture-RNA Homo sapiens 19 RPS20 6224 Proximity Label-MS Homo sapiens 20 GSPT2 23708 Affinity Capture-MS Homo sapiens 21 B3GNT2 10678 Affinity Capture-MS Homo sapiens 22 KIF23 9493 Affinity Capture-MS Homo sapiens 23 SPRTN   Affinity Capture-MS Homo sapiens 24 LENG1   Two-hybrid Homo sapiens 25 PRC1 9055 Two-hybrid Homo sapiens 26 NPM1 4869 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 27 Hnrnpk 15387 Two-hybrid Mus musculus 28 FBL 2091 Proximity Label-MS Homo sapiens 29 RPS12 6206 Co-fractionation Homo sapiens 30 OBSL1 23363 Affinity Capture-MS Homo sapiens 31 EXD2   Proximity Label-MS Homo sapiens 32 Kif2a 16563 Affinity Capture-MS Mus musculus 33 FBXW8 26259 Affinity Capture-MS Homo sapiens 34 CALR 811 Co-fractionation Homo sapiens 35 Eif3a 13669 Affinity Capture-MS Mus musculus 36 RNF126   Affinity Capture-MS Homo sapiens 37 MYCN   Affinity Capture-MS Homo sapiens 38 RBM42   Affinity Capture-MS Homo sapiens 39 MARCH5   Proximity Label-MS Homo sapiens 40 RBM8A 9939 Affinity Capture-MS Homo sapiens 41 KIF14 9928 Affinity Capture-MS Homo sapiens 42 LARP4B 23185 Affinity Capture-MS Homo sapiens 43 LIN28A   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 44 CPEB1   Proximity Label-MS Homo sapiens 45 PRPF6 24148 Two-hybrid Homo sapiens 46 SRP9 6726 Affinity Capture-MS Homo sapiens 47 WBP4   Two-hybrid Homo sapiens 48 MTCH2 23788 Proximity Label-MS Homo sapiens 49 RNF4 6047 Affinity Capture-MS Homo sapiens 50 LIN28B   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 51 RPS10 6204 Co-fractionation Homo sapiens 52 HIST1H2AG 8969 Cross-Linking-MS (XL-MS) Homo sapiens 53 SRSF3 6428 Affinity Capture-MS Homo sapiens 54 YBX2 51087 Affinity Capture-MS Homo sapiens 55 MAPRE1 22919 Affinity Capture-MS Homo sapiens 56 RPL5 6125 Affinity Capture-MS Homo sapiens 57 Pabpc1 18458 Affinity Capture-MS Mus musculus 58 AKAP1 8165 Affinity Capture-MS Homo sapiens Proximity Label-MS Homo sapiens Proximity Label-MS Homo sapiens 59 POU6F2   Two-hybrid Homo sapiens 60 PFDN2 5202 Affinity Capture-MS Homo sapiens 61 Srp72   Affinity Capture-MS Mus musculus 62 NTRK1 4914 Affinity Capture-MS Homo sapiens 63 IFI16 3428 Affinity Capture-MS Homo sapiens 64 TGM5   Two-hybrid Homo sapiens 65 HECTD1 25831 Affinity Capture-MS Homo sapiens 66 Fubp3   Two-hybrid Mus musculus 67 TXNL4A 10907 Two-hybrid Homo sapiens 68 RHOT2 89941 Proximity Label-MS Homo sapiens 69 RMDN3 55177 Proximity Label-MS Homo sapiens 70 MAT2A 4144 Cross-Linking-MS (XL-MS) Homo sapiens 71 FNDC3B 64778 Two-hybrid Homo sapiens 72 S100P 6286 Affinity Capture-MS Homo sapiens 73 Rbm38   Two-hybrid Mus musculus 74 RPS2 6187 Co-fractionation Homo sapiens 75 RC3H2   Affinity Capture-MS Homo sapiens 76 RBM47 54502 Affinity Capture-MS Homo sapiens 77 SIRT7   Affinity Capture-MS Homo sapiens 78 SRSF1 6426 Affinity Capture-MS Homo sapiens 79 CUL3 8452 Affinity Capture-MS Homo sapiens 80 BHLHE40   Two-hybrid Homo sapiens 81 EGFR 1956 Affinity Capture-MS Homo sapiens 82 FKBP8 23770 Proximity Label-MS Homo sapiens 83 MYC   Affinity Capture-MS Homo sapiens 84 MYO1C 4641 Affinity Capture-MS Homo sapiens 85 OCIAD1 54940 Proximity Label-MS Homo sapiens 86 CRX   Two-hybrid Homo sapiens 87 RPS27 6232 Co-fractionation Homo sapiens 88 PRR3   Affinity Capture-MS Homo sapiens 89 PSPC1 55269 Affinity Capture-MS Homo sapiens 90 EIF2D 1939 Co-fractionation Homo sapiens 91 PABPC5 140886 Affinity Capture-MS Homo sapiens 92 KAT5   Two-hybrid Homo sapiens 93 BCAS2 10286 Two-hybrid Homo sapiens 94 MFN2 9927 Proximity Label-MS Homo sapiens 95 DDRGK1 65992 Affinity Capture-MS Homo sapiens 96 PCM1 5108 Two-hybrid Homo sapiens 97 NUP35 129401 Proximity Label-MS Homo sapiens 98 PFDN5 5204 Two-hybrid Homo sapiens 99 RBMS2 5939 Affinity Capture-MS Homo sapiens 100 RPS16 6217 Affinity Capture-MS Homo sapiens 101 PAIP1 10605 Affinity Capture-MS Homo sapiens 102 PLEKHA4 57664 Affinity Capture-MS Homo sapiens 103 SIRT6   Affinity Capture-MS Homo sapiens 104 ILF3 3609 Affinity Capture-RNA Homo sapiens 105 OMP   Affinity Capture-MS Homo sapiens 106 FBXO10   Affinity Capture-MS Homo sapiens 107 MNDA 4332 Affinity Capture-MS Homo sapiens 108 DDX3X 1654 Co-fractionation Homo sapiens 109 Ccdc77   Affinity Capture-MS Mus musculus 110 SRP19 6728 Affinity Capture-MS Homo sapiens 111 PFDN1 5201 Affinity Capture-MS Homo sapiens 112 PAX5   Two-hybrid Homo sapiens 113 ELAVL1 1994 Affinity Capture-RNA Homo sapiens 114 G3BP2 9908 Affinity Capture-MS Homo sapiens 115 LSM5   Two-hybrid Homo sapiens 116 PRKACA 5566 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 117 YTHDF3   Two-hybrid Homo sapiens 118 PRPF39 55015 Two-hybrid Homo sapiens 119 TRIM31   Affinity Capture-MS Homo sapiens 120 TPST2 8459 Affinity Capture-MS Homo sapiens 121 SERBP1 26135 Proximity Label-MS Homo sapiens 122 GNB2L1 10399 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 123 RC3H1 149041 Affinity Capture-MS Homo sapiens 124 PRMT1 3276 Affinity Capture-MS Homo sapiens 125 ZNF830   Two-hybrid Homo sapiens 126 EP300 2033 Affinity Capture-MS Homo sapiens View the network

Pathways in which LARP4 is involved

No pathways found