Gene description for CHD2
Gene name chromodomain helicase DNA binding protein 2
Gene symbol CHD2
Other names/aliases EEOC
Species Homo sapiens
 Database cross references - CHD2
ExoCarta ExoCarta_1106
Vesiclepedia VP_1106
Entrez Gene 1106
HGNC 1917
MIM 602119
UniProt O14647  
 CHD2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CHD2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISS
    DNA binding GO:0003677 IBA
    chromatin binding GO:0003682 IBA
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    four-way junction helicase activity GO:0009378 IEA
    ATP hydrolysis activity GO:0016887 IBA
    double-stranded DNA helicase activity GO:0036121 IEA
    histone binding GO:0042393 IBA
    histone binding GO:0042393 ISS
    forked DNA-dependent helicase activity GO:0061749 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent chromatin remodeler activity GO:0140658 IBA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
    single-stranded 3'-5' DNA helicase activity GO:1990518 IEA
Biological Process
    DNA damage response GO:0006974 IEA
    muscle organ development GO:0007517 ISS
    gene expression GO:0010467 IEA
    DNA duplex unwinding GO:0032508 IEA
    nucleosome organization GO:0034728 IBA
    hematopoietic stem cell differentiation GO:0060218 IEA
    chromatin looping GO:0140588 IEA
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
 Experiment description of studies that identified CHD2 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CHD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 ALCAM 214
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
4 TEKT1  
Two-hybrid Homo sapiens
5 MECP2 4204
Affinity Capture-MS Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 MYCN  
Affinity Capture-MS Homo sapiens
8 CTR9 9646
Co-fractionation Homo sapiens
9 LEO1 123169
Co-fractionation Homo sapiens
10 NR3C1 2908
Proximity Label-MS Homo sapiens
11 SRPK2 6733
Biochemical Activity Homo sapiens
12 SIRT7  
Affinity Capture-MS Homo sapiens
13 TRIM41 90933
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 KIF20A 10112
Affinity Capture-MS Homo sapiens
15 DDX21 9188
Cross-Linking-MS (XL-MS) Homo sapiens
16 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
17 ZNF398  
Two-hybrid Homo sapiens
18 FAM35A  
Proximity Label-MS Homo sapiens
19 TRIM54  
Two-hybrid Homo sapiens
20 THAP1  
Two-hybrid Homo sapiens
21 DDX23 9416
Proximity Label-MS Homo sapiens
22 TAF9 6880
Co-fractionation Homo sapiens
23 SUV420H2  
Affinity Capture-MS Homo sapiens
24 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
25 BEND7 222389
Two-hybrid Homo sapiens
26 MEOX2  
Two-hybrid Homo sapiens
27 PAF1 54623
Co-fractionation Homo sapiens
28 TCEB3B  
Two-hybrid Homo sapiens
29 SSRP1 6749
Affinity Capture-MS Homo sapiens
30 MID2 11043
Two-hybrid Homo sapiens
31 EED  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CHD2 is involved
No pathways found





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