Gene description for INA
Gene name internexin neuronal intermediate filament protein, alpha
Gene symbol INA
Other names/aliases NEF5
NF-66
TXBP-1
Species Homo sapiens
 Database cross references - INA
ExoCarta ExoCarta_9118
Vesiclepedia VP_9118
Entrez Gene 9118
HGNC 6057
MIM 605338
UniProt Q16352  
 INA identified in sEVs derived from the following tissue/cell type
Liver cancer cells 25265333    
 Gene ontology annotations for INA
Molecular Function
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
    structural constituent of postsynaptic intermediate filament cytoskeleton GO:0099184 IBA
Biological Process
    substantia nigra development GO:0021762 HEP
    cell differentiation GO:0030154 IEA
    intermediate filament organization GO:0045109 IBA
    neurofilament cytoskeleton organization GO:0060052 IEA
    postsynaptic modulation of chemical synaptic transmission GO:0099170 IEA
    postsynaptic intermediate filament cytoskeleton organization GO:0099185 IEA
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    extracellular space GO:0005615 HDA
    cytoplasm GO:0005737 IBA
    intermediate filament GO:0005882 IBA
    neurofilament GO:0005883 IEA
    cytoplasmic ribonucleoprotein granule GO:0036464 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    postsynaptic intermediate filament cytoskeleton GO:0099160 IBA
 Experiment description of studies that identified INA in sEVs
1
Experiment ID 267
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for INA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ECT2L  
Affinity Capture-MS Homo sapiens
2 SPRTN  
Affinity Capture-MS Homo sapiens
3 ARHGEF19  
Affinity Capture-MS Homo sapiens
4 SYCE1  
Affinity Capture-MS Homo sapiens
5 VSIG8  
Affinity Capture-MS Homo sapiens
6 FGD1  
Affinity Capture-MS Homo sapiens
7 GFAP 2670
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 BFSP2  
Affinity Capture-MS Homo sapiens
11 CAPN12  
Affinity Capture-MS Homo sapiens
12 WHAMMP3  
Affinity Capture-MS Homo sapiens
13 OBSL1 23363
Affinity Capture-MS Homo sapiens
14 KRT31 3881
Affinity Capture-MS Homo sapiens
15 KRT78 196374
Affinity Capture-MS Homo sapiens
16 BRD4 23476
Affinity Capture-MS Homo sapiens
17 KRT72 140807
Affinity Capture-MS Homo sapiens
18 TIAL1 7073
Affinity Capture-MS Homo sapiens
19 MECP2 4204
Affinity Capture-MS Homo sapiens
20 TFCP2 7024
Affinity Capture-MS Homo sapiens
21 MYCN  
Affinity Capture-MS Homo sapiens
22 SLU7  
Affinity Capture-MS Homo sapiens
23 KIF14 9928
Affinity Capture-MS Homo sapiens
24 ARHGEF11 9826
Affinity Capture-MS Homo sapiens
25 KRT8 3856
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
26 CAMK2A 815
Affinity Capture-MS Homo sapiens
27 PPP1CA 5499
Affinity Capture-MS Homo sapiens
28 BAZ2B  
Affinity Capture-MS Homo sapiens
29 KRT39  
Affinity Capture-MS Homo sapiens
30 PRPH 5630
Proximity Label-MS Homo sapiens
31 RB1CC1 9821
Affinity Capture-MS Homo sapiens
32 PARK2  
Affinity Capture-MS Homo sapiens
33 CTBP1 1487
Affinity Capture-MS Homo sapiens
34 STAU1 6780
Affinity Capture-MS Homo sapiens
35 PSMD14 10213
Affinity Capture-MS Homo sapiens
36 CERS2 29956
Affinity Capture-MS Homo sapiens
37 GJB7  
Affinity Capture-MS Homo sapiens
38 CHMP4B 128866
Affinity Capture-MS Homo sapiens
39 YAP1 10413
Affinity Capture-MS Homo sapiens
40 NTRK1 4914
Affinity Capture-MS Homo sapiens
41 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 KRT14 3861
Affinity Capture-MS Homo sapiens
43 KRT2 3849
Affinity Capture-MS Homo sapiens
44 RAB11FIP5 26056
Co-fractionation Homo sapiens
45 CAPN1 823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 GAN 8139
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 S100P 6286
Affinity Capture-MS Homo sapiens
48 MAP7 9053
Affinity Capture-MS Homo sapiens
49 VWA3B 200403
Affinity Capture-MS Homo sapiens
50 CENPP  
Affinity Capture-MS Homo sapiens
51 ECT2 1894
Affinity Capture-MS Homo sapiens
52 KRT86  
Affinity Capture-MS Homo sapiens
53 SIRT7  
Affinity Capture-MS Homo sapiens
54 CCDC120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 KRT32  
Affinity Capture-MS Homo sapiens
56 PRMT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DES 1674
Affinity Capture-MS Homo sapiens
58 MAB21L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 NAP1L1 4673
Affinity Capture-MS Homo sapiens
60 KRT27 342574
Affinity Capture-MS Homo sapiens
61 ABTB2 25841
Affinity Capture-MS Homo sapiens
62 KLHL36  
Affinity Capture-MS Homo sapiens
63 NEFM 4741
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 NIN 51199
Proximity Label-MS Homo sapiens
65 DLST 1743
Affinity Capture-MS Homo sapiens
66 BICD1 636
Proximity Label-MS Homo sapiens
67 BMP1 649
Affinity Capture-MS Homo sapiens
68 KRT19 3880
Proximity Label-MS Homo sapiens
69 AKAP1 8165
Proximity Label-MS Homo sapiens
70 KRT16 3868
Affinity Capture-MS Homo sapiens
71 NES 10763
Affinity Capture-MS Homo sapiens
72 KRT18 3875
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
73 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
74 ANKFY1 51479
Proximity Label-MS Homo sapiens
75 EZR 7430
Proximity Label-MS Homo sapiens
76 RSPRY1 89970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 PDHA1 5160
Affinity Capture-MS Homo sapiens
78 SQSTM1 8878
Affinity Capture-MS Homo sapiens
79 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
80 ERGIC1 57222
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 NEFH 4744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 IDE 3416
Affinity Capture-MS Homo sapiens
83 ARRB1 408
Affinity Capture-MS Homo sapiens
84 CEP135  
Proximity Label-MS Homo sapiens
85 MIPEP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 KRT23  
Affinity Capture-MS Homo sapiens
87 CUL7 9820
Affinity Capture-MS Homo sapiens
88 ARHGAP23 57636
Affinity Capture-MS Homo sapiens
89 CCDC96  
Affinity Capture-MS Homo sapiens
90 MYC  
Affinity Capture-MS Homo sapiens
91 VIM 7431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 PRMT1 3276
Affinity Capture-MS Homo sapiens
93 KRT7 3855
Affinity Capture-MS Homo sapiens
94 AIM1 202
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which INA is involved
No pathways found





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