Gene description for Tln1
Gene name talin 1
Gene symbol Tln1
Other names/aliases Tln
Species Rattus norvegicus
 Database cross references - Tln1
ExoCarta ExoCarta_313494
Vesiclepedia VP_313494
Entrez Gene 313494
 Tln1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Tln1
Molecular Function
    phosphatidylserine binding GO:0001786 ISO
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 IPI
    integrin binding GO:0005178 ISO
    structural constituent of cytoskeleton GO:0005200 IEA
    vinculin binding GO:0017166 ISO
    LIM domain binding GO:0030274 ISO
    phosphatidylinositol binding GO:0035091 ISO
    actin filament binding GO:0051015 IEA
Biological Process
    cell-substrate junction assembly GO:0007044 ISO
    integrin-mediated signaling pathway GO:0007229 ISO
    biological_process GO:0008150 ND
    actin cytoskeleton organization GO:0030036 IBA
    cortical actin cytoskeleton organization GO:0030866 ISO
    integrin activation GO:0033622 ISO
    cortical microtubule organization GO:0043622 IEA
    cortical microtubule organization GO:0043622 ISO
    platelet aggregation GO:0070527 ISO
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    ruffle GO:0001726 IEA
    cytoplasm GO:0005737 IBA
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IBA
    adherens junction GO:0005912 ISO
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 ISO
 Experiment description of studies that identified Tln1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Tln1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dmd  
Affinity Capture-Western Rattus norvegicus
2 Fbxo21  
Affinity Capture-MS Rattus norvegicus
3 PIP5K1C  
Reconstituted Complex Homo sapiens
4 Itgb1 24511
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Tln1 is involved
No pathways found





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