Gene description for Ubxn1
Gene name UBX domain protein 1
Gene symbol Ubxn1
Other names/aliases 2B28
RGD1309471
Species Rattus norvegicus
 Database cross references - Ubxn1
ExoCarta ExoCarta_293719
Vesiclepedia VP_293719
Entrez Gene 293719
 Ubxn1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Ubxn1
Molecular Function
    protein binding GO:0005515 IPI
    polyubiquitin modification-dependent protein binding GO:0031593 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 IBA
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 ISO
    ubiquitin binding GO:0043130 ISO
    ATPase binding GO:0051117 ISO
    K6-linked polyubiquitin modification-dependent protein binding GO:0071796 ISO
    K6-linked polyubiquitin modification-dependent protein binding GO:0071796 ISS
    proteasome regulatory particle binding GO:1904855 ISO
Biological Process
    negative regulation of protein ubiquitination GO:0031397 IBA
    negative regulation of protein ubiquitination GO:0031397 ISO
    negative regulation of protein ubiquitination GO:0031397 ISS
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IBA
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISO
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISS
    negative regulation of protein K48-linked deubiquitination GO:1903094 IBA
    negative regulation of protein K48-linked deubiquitination GO:1903094 ISO
    negative regulation of ERAD pathway GO:1904293 ISO
    negative regulation of ubiquitin-specific protease activity GO:2000157 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 ISO
    cytosol GO:0005829 ISO
    dendrite GO:0030425 IDA
    VCP-NPL4-UFD1 AAA ATPase complex GO:0034098 ISO
    neuronal cell body GO:0043025 IDA
 Experiment description of studies that identified Ubxn1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Ubxn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rad23b  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Ubxn1 is involved
No pathways found





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