Gene description for Dcn
Gene name decorin
Gene symbol Dcn
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Dcn
ExoCarta ExoCarta_29139
Vesiclepedia VP_29139
Entrez Gene 29139
UniProt Q01129  
 Dcn identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Dcn
Molecular Function
    collagen binding GO:0005518 IDA
    glycosaminoglycan binding GO:0005539 IEA
    glycosaminoglycan binding GO:0005539 ISO
    extracellular matrix binding GO:0050840 IEA
    extracellular matrix binding GO:0050840 ISO
Biological Process
    kidney development GO:0001822 IEP
    placenta development GO:0001890 IEP
    skeletal muscle tissue development GO:0007519 IEP
    response to mechanical stimulus GO:0009612 IEP
    positive regulation of autophagy GO:0010508 ISO
    negative regulation of endothelial cell migration GO:0010596 IEA
    negative regulation of endothelial cell migration GO:0010596 ISO
    positive regulation of macroautophagy GO:0016239 IEA
    positive regulation of macroautophagy GO:0016239 ISO
    negative regulation of angiogenesis GO:0016525 IEA
    negative regulation of angiogenesis GO:0016525 ISO
    response to lipopolysaccharide GO:0032496 IEP
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    positive regulation of mitochondrial depolarization GO:0051901 IEA
    positive regulation of mitochondrial depolarization GO:0051901 ISO
    positive regulation of mitochondrial fission GO:0090141 IEA
    positive regulation of mitochondrial fission GO:0090141 ISO
    negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 IEA
    negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    collagen type VI trimer GO:0005589 IDA
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified Dcn in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Dcn
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
2 Gja1  
Affinity Capture-MS Rattus norvegicus
3 Otub1 293705
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
4 Ubc  
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml



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